丹皮多糖-2b降血糖作用的实验研究

Experimental study of the hypoglycemic activity of cortex moutan polysaccharide-2b

目的 :研究丹皮多糖 2b (CMP 2b)降血糖作用及作用机制。方法 :用小鼠和大鼠建立葡萄糖性高血糖及四氧嘧啶性糖尿病模型 ,氢化可的松琥珀酸纳 (HCSS)诱导胰岛素抵抗 ,观察丹皮多糖 2b对正常和高血糖模型动物的影响 ,并测定糖尿病动物SOD、Insulin、GHb、ApoA1等水平。结果 :CMP 2b可降低葡萄糖和四氧嘧啶诱发的鼠高血糖 ,并能升高糖尿病小鼠SOD和大鼠ApoA1水平 ,降低GHb水平 ,改善小鼠胰岛素抵抗。结论 :CMP 2b可有效地控制实验性高血糖 ,其降糖机理可能与改善机体对胰岛素的敏感性 ,促进外周组织对葡萄糖的利用有关。

AIM: To study the hypoglycemic action of cortex moutan polysaccharide 2b (CMP 2b) and the its mechanism. METHODS: Some animal models in this study included the glucose induced hyperglycemic model in mice, the alloxan induced diabetic model in mice and rats, and the HCSS induced insulin resistance model in mice. Those models were used to investigate the effects of CMP 2b on blood glucose of normal and hyperglycemic model animals, on serum superoxide dismutase (SOD), serum insulin, glycated hemoglobin (GHb), and apolipoproteinA 1 (ApoA 1) in alloxan diabetic animals. RESULTS: CMP 2b significantly lowered the blood glucose in hyperglycemic mice and rats induced by glucose and alloxan. CMP 2b also raised the SOD and ApoA 1 level, decreased the GHb level in diabetic animals, and improved insulin resistance in mice. CONCLUSION: CMP 2b can control experimental hyperglycemia. Its mechanism is related to improving insulin sensitivity and enhancing the utilization of glucose in peripheral tissues.