阿司匹林对卡托普利治疗充血性心力衰竭的影响

Influence of aspirin on the efficacy of captopril in the treatment of chronic congestive heart failure

目的 :观察阿司匹林对卡托普利治疗充血性心力衰竭的影响。方法 :将 74例CHF患者按入院前是否服用阿司匹林分为 2组 ,均给予卡托普利12 .5mg口服 ,tid ,并逐渐加量为 2 5mg ,tid ,连服2 8d。结果 :未用阿司匹林组显效率为 4 6 .7% ,总有效率为 70 % ,与曾用阿司匹林组相比差异显著 (P <0 .0 5 ) ;患者心率明显下降 ,优于曾用阿司匹林组 (P<0 .0 5 ) ;心脏收缩功能参数LVEF、FS以及舒张功能参数E/A明显增加 (P <0 .0 1) ,且较曾用阿司匹林组为优 (P <0 .0 5 )。结论 :曾经应用阿司匹林的时间越长 ,卡托普利治疗CHF的效果越差。

AIM: To investigate the influence of aspirin on the efficacy of captopril in the treatment of chronic congestive heart failure (CHF). METHODS: 74 cases of CHF were divided into 2 groups depending on whether aspirin was administrated before captopril was given, then all patients were given captopril 12.5 - 25 mg , tid, for 28 days. RESULTS: In aspirin group, marked effective rate was 46.7 %, and total effective rate was 70%, superior to that in no aspirin group (P< 0.05 ). The heart rate (HR) evidently decreased (P< 0.05 ) in aspirin group. Other indices, including the left ventricular ejection fraction (LVEF),fraction shortening (FS) and the rate of filling velocity in early diastole over that in late diastole (E/A), were significantly increased (P< 0.01 ) in aspirin group. CONCLUSION: The longer is the administration of aspirin, the poorer is the effects of captopril added in the treatment of CHF.