MMP-2和RECK蛋白在子宫腺肌病内膜组织中的表达及意义

Expressions and Significances of MMP-2 and RECK Proteins in Intimal Tissue of Adenomyosis

目的研究基质金属蛋白酶-2(MMP-2)和RECK蛋白在子宫腺肌病(AM)内膜组织中的表达及其意义。方法选择2015年6月—2017年11月收治的AM患者30例作为观察对象,收集患者肌层异位内膜(异位组)和非异位内膜(非异位组)。并选取同期25例子宫肌瘤患者的非瘤区内膜作为对照组。观察不同子宫内膜组织中MMP-2和RECK蛋白的表达情况。结果异位组MMP-2阳性表达率明显高与对照组(P<0.05)。异位组RECK阳性表达率低于非异位组和对照组(P<0.05)。异位组MMP-2蛋白表达积分高于非异位组和对照组,且非异位组高于对照组(P<0.05)。异位组RECK蛋白表达积分低于非异位组和对照组(P<0.05)。结论 MMP-2和RECK蛋白的异常表达可能在AM发病过程中发挥重要作用。

Objective To investigate expressions and significance of matrix metalloproteinase-2（ MMP-2） and reversion-inducing cysteine-rich protein with Kazal motifs（ RECK） protein in intimal tissue of adenomyosis（ AM）.Methods Myometrium ectopic endometrium（ ectopic group） and non ectopic endometrium（ non ectopic group） samples were collected from 30 AM patients admitted during June 2015 and November 2017,and samples of non neoplastic endometrium were selected from 25 patients with uterine fibroids at the same period as control group. Expressions of MMP-2 and RECK proteins in different endometrium tissues were observed. Results In ectopic group,positive expression rate of MMP-2 was significantly higher than that in control group（ P〈0. 05）; positive expression rate of RECK was significantly lower than those in non ectopic and control groups（ P〈0. 05）. Expression integration of MMP-2 protein in ectopic group was significantly higher than those in non ectopic and control groups,and the value in non ectopic group was significantly higher than that in control group（ P〈0. 05）. Expression integration of RECK protein in ectopic group was significantly lower than that in non ectopic and control group（ P〈0. 05）. Conclusion Abnormal expressions of RECK and MMP-2 proteins may play an important roles in development of AM.