间苯三酚对肠易激综合征患者肠道痉挛的应用分析

Effect of Phloroglucinol in Intestinal Spasm in Patients with Irritable Bowel Syndrome

目的分析间苯三酚对肠易激综合征(IBS)患者肠道痉挛的作用。方法回顾性分析2014年11月—2016年11月收治的60例腹泻型IBS患者的临床资料,按治疗方法分为对照组和观察组,每组30例。对照组给予常规疗法联合马来酸曲美布汀和双歧杆菌三联活菌胶囊,观察组在对照组基础上给予间苯三酚,比较两组腹痛缓解时间、疼痛评分、症状积分、肠道菌群变化、临床疗效及不良反应情况。结果对照组腹痛缓解时间长于观察组,用药后30 min疼痛视觉模拟评分高于观察组(P<0.01)。治疗后,两组腹痛积分、腹泻积分、腹胀积分和症状总积分较治疗前均显著降低,且观察组降低幅度大于对照组(P<0.05);两组双歧杆菌、乳酸杆菌、肠道定植抗力较治疗前显著上升,肠杆菌、肠球菌、拟杆菌较治疗前显著下降(P<0.05)。观察组总有效率高于对照组(P<0.05)。两组治疗期间均未见明显不良反应。结论间苯三酚可明显改善腹泻型IBS患者肠道痉挛疼痛情况,缓解症状,提升治疗效果。

Objective To analyze effect of Phloroglucinol in intestinal spasm in patients with irritable bowel syndrome（ IBS）. Methods Clinical data of 60 patients with diarrhea-predominant IBS admitted during November 2014 and November 2016 was retrospectively analyzed,and the patients were divided into control group and observation group（ n =30 for each group） according to therapeutic methods. Control group was given conventional therapy combined with Trimebutine Maleate and Bifidobacterium triple viable organism capsule,while observation group were added with Phloroglucinol on the basis of treatment for control group. In two groups,relief time of abdominal pain,pain score,symptom score,intestinal flora change,curative effect and adverse reaction were compared. Results In control group,relief time of abdominal pain was longer,and visual simulation score at 30 min after medication was higher than those in observation group（ P〈0. 01）. After treatment,the integration scores of abdominal pain,diarrhea,abdominal distention and total integration score of symptoms in the two groups were significantly lower than those before treatment in two groups,and the decrease degrees in observation group were significantly larger than those in control group（ P〈0. 05）; in two groups,values of bifidobacteria,lactobacillus and intestinal colonization resistance were significantly increased,while levels of enterobacteria,enterococcus and bacteroides were significantly decreased compared with those before treatment（ P〈0. 05）. The total effective rate in observation group was higher than that in control group（ P〈0. 05）. There was no obvious adverse reaction during treatment in two groups. Conclusion Phloroglucinol may significantly improve pain condition of intestinal spasm,relieve symptoms and enhance curative effect of patients with diarrhea-predominant IBS.