氨磺必利治疗阴性症状为主精神分裂症的疗效

Analysis of Amisulpride in the Treatment of Schizophrenia With Negative Symptoms

目的探讨氨磺必利与氯氮平治疗阴性症状为主精神分裂患者的效果,以期提高患者的生活质量。方法随机将我院2016年10月—2017年10月收治的90例阴性症状为主精神分裂症患者分为两组,每组45例。对照组给予氯氮平,观察组给予氨磺必利。比较两组临床疗效。结果两组总有效率比较差异无统计学意义(P>0.05);观察组不良反应发生率、生活质量评分等指标均明显优于对照组(P<0.05)。结论氨磺必利与氯氮平均可有效治疗阴性症状为主的精神分裂症,但前者不良反应少,不仅提高了患者的生活质量,同时也改善了患者的治疗依从性,保障了临床用药的安全性。

Objective To explore the effect of amisulpride and clozapine in the treatment of schizophrenia with negative symptoms, in order to improve their quality of life. Methods A total of 90 schizophrenic patients with negative symptoms in our hospital from October 2016 to October 2017 were randomly divided into two groups, 45 cases in each group. The control group was given clozapine, and the observation group was given amisulpride. The clinical effects of two groups were compared. Results There was no significant difference in the total effective rate between the two groups（P〉0.05）. The incidence of adverse reactions and quality of life scores in the observation group were significantly better than those in the control group（P〈0.05）. Conclusion Amisulpride and clozapine can effectively treat schizophrenia with negative symptoms, but the former has less adverse reactions, it not only improves the quality of life of the patients, but also improves the compliance of the patients, and ensures the safety of the clinical medication.