丙戊酸钠治疗精神分裂症攻击行为疗效分析

Efficacy of Valproate in the Treatment of Aggressive Behavior in Schizophrenia

目的观察利培酮联合丙戊酸钠治疗精神分裂症攻击行为的临床价值,并记录不良反应,以确保用药的安全性。方法随机将我院2016年9月—2017年9月收治的84例精神分裂症伴有攻击行为患者分为两组,每组42例。对照组给予利培酮治疗,观察组在对照组的基础上给予丙戊酸钠治疗。比较两组MOAS评分、BPRS评分等指标。结果治疗后,观察组总有效率、MOAS评分、BPRS评分以及不良反应发生率等均优于对照组(P<0.05)。结论利培酮联合丙戊酸钠治疗精神分裂症效果理想,可显著缓解其攻击行为以及临床症状,且不良反应少,安全可靠。

Objective To observe the clinical value of risperidone combined with valproate in the treatment of aggressive behavior of schizophrenia, and to record the adverse reactions in order to ensure the safety of the drugs. Methods 84 schizophrenic patients with aggressive behavior in our hospital from September 2016 to September 2017 were randomly divided into two groups, 42 cases in each group. The control group was given risperidone, while the observation group was given valproate treatment on the basis of control group. The MOAS score and BPRS score were compared between the two groups. Results After treatment, the total effective rate, MOAS score, BPRS score and incidence of adverse reactions of observation group were significantly better than those in the control group（P〈0.05）. Conclusion The effect of risperidone combined with valproate in the treatment of schizophrenia is ideal, it can significantly alleviate the attack and clinical symptoms, with less adverse reactions, safe and reliable.