糖尿病肾病发病机制的研究进展

Research Progress in the Pathogenesis of Diabetic Nephropathy

糖尿病肾病是最常见的糖尿病微血管并发症之一,可导致肾功能衰竭,但目前尚无有效的治疗方法。近年来的研究显示,除了高血糖这一公认的因素外,细胞因子(TGF-β、TNF-α等)、氧化应激、自噬行为异常、表观遗传等均参与了糖尿病肾病的发生发展进程。现对该病发病机制的研究进展作一综述。

Diabetic nephropathy（DN） is one of the most common complications of diabetes mellitus,which can lead to renal failure. Currently, there is no effective therapy for DN, therefore, it is very important to recognize its pathogenesis to guide the development of new drugs. In addition to high blood glucose, many other factors have recently been recognized to be involved in the development and progression of DN, such as cytokines TGF-β and TNF-α, oxidative stress, abnormal autophagy and epigenetics. This article reviews the research progress of the pathogenesis of DN in recent years.