加味四二汤合六味地黄丸加减对早期糖尿病肾病疗效及对患者免疫功能影响

Effect of modified Si'er decoction and Liuwei Dihuang wan on efficacy and immune function in patients with early diabetic nephropathy

目的:探讨加味四二汤合六味地黄丸加减对早期糖尿病肾病患者疗效及免疫功能影响性。方法:选择114例早期糖尿病肾病患者为研究对象,分成两组,对照组57例,常规西药治疗,研究组57例,加味四二汤合六味地黄丸加减治疗,观察不同方法治疗8周后疗效、症状和免疫功能变化情况。结果:疗效上,治疗8周后对照组显效率33.33%、总有效率77.19%,研究组显效率49.12%、总有效率89.47%,两组比较差异有统计学意义(P<0.05);两组治疗8周后症状指标均有改善,但研究组症状下降水平显著优于对照组(P<0.05);两组治疗8周后FPG、2hPG、HbAIc较治疗前均显著下降(P<0.05),但治疗8周后差异无统计学意义(P>0.05),对照组CD4+、CD8+、CD4+/CD8+水平治疗前和治疗8周后无显著差异(P>0.05),研究组CD4+、CD8+、CD4+/CD8+改善水平显著优于对照组(P<0.05)。结论:加味四二汤合六味地黄丸加减治疗早期糖尿病肾病能提高疗效,增强免疫力,改善症状。

Objective：To investigate the effect of modified Si＇er decoction and Liuwei Dihuang wan on the curative effect and immune function of patients with early diabetic nephropathy.Methods：One hundred and fortyfour patients with early diabetic nephropathy were enrolled in this study.The patients were divided into two groups：control group（n=57）,conventional western medicine（n=57）,study group（n=57）efficacy,modified Si＇er decoction and Liuwei Dihuang wan were used,symptoms and changes in immune function.Results：In the treatment group,the effective rate of the control group was 33.33% and the total effective rate was 77.19% after 8 weeks of treatment.The effective rate was 49.12%and the total effective rate was 89.47%in the study group,with significant difference between the two groups（P〈0.05）Symptoms were improved after 2 weeks,but the decrease of symptom in study group was significantly better than that in control group（P〈0.05）.FPG,2 hPG and HbAIc in two groups were significantly decreased（P〈0.05）8 weeks after treatment,but treatment The levels of CD_4^＋,CD_8^＋and CD_4^＋/CD_8^＋in the control group had no significant difference between before treatment and after 8 weeks of treatment（P〉 0.05）after 8 weeks,and the improvement of CD_4^＋,CD_8^＋,CD4＋/CD8＋The level was significantly better than the control group（P〈0.05）.Conclusion：Modified si＇er decoction and Liuwei Dihuang wan addition and subtraction treatment of early diabetic nephropathy can improve efficacy,enhance immunity and improve symptoms.