丹参川芎嗪注射液联合黄芪注射液对早期糖尿病肾病患者尿UAER、UACR、β2-MG及血清IL-6、IL-18、TNF-α的影响研究

The study of Danshen Ligustrazine injection combined with astragalus injection on urinary UAER-UACR-β 2-MG and Serum IL-6 IL-18 TNF-α in patients with early diabetic nephropathy

目的:观察早期糖尿病肾病患者采用丹参川芎嗪注射液联合黄芪注射液治疗后的临床疗效及对体内炎症因子的影响。方法:选择96例早期糖尿病肾患者临床资料,分为对照组和研究组。对照组45例,采用丹参川芎嗪注射液进行治疗,研究组51例,在对照组基础上加用黄芪注射液联合治疗。治疗4周后,观察两组患者临床疗效,比较两组中医症候积分,对两组患者尿UAER、UACR、β2-MG水平与血清IL-6、IL-18、TNF-α水平进行比较。结果:治疗4周后对照组的临床总有效率为77.78%,研究组的治疗总有效率为88.24%,研究组明显高于对照组两组比较差异具有统计学意义(P<0.05);治疗前两组患者尿UAER、UACR、β2-MG水平与血清IL-6、IL-18、TNF-α水平差异无统计学意义(P>0.05),治疗后两组患者尿UAER、UACR、β2-MG水平与血清IL-6、IL-18、TNF-α水平明显改善,组间比较差异具有统计学意义(P<0.05)。结论:丹参川芎嗪注射液联合黄芪注射液治疗早期糖尿病肾病患者能够有效改善患者各中医症候,改善肾脏功能降低患者体内各炎症因子,临床治疗效果明显。

Objective：to observe the effect of Dan shen ligustrazine injection combined with astragalus injection on inflammatory factors in patients with early diabetic nephropathy.Methods：the clinical data of 101 patients with early diabetic kidney were retrospectively analyzed and divided into two groups：control group and study group.The control group（n=45）was treated with Danshen ligustrazine injection and the study group（n=56）was treated with astragalus injection on the basis of the control group.After 4 weeks of treatment,the clinical efficacy of the two groups was observed,and the scores of TCM symptoms in the two groups were compared.The levels of UACR-β2-MG and serum IL-6,IL-18,TNF-αwere compared between the two groups.Results：the total clinical effective rate of the control group was 77.78% weeks after treatment,and the total effective rate of the study group was 88.24%,which was significantly higher than that of the control group（P〈0.05）,and the levels of UAER-UACR,β2-MG and serum in the two groups before treatment were significantly higher than those in the control group（P〈0.05）.There was no significant difference in the level of IL-18 and TNF-αbetween the two groups（P〉0.05）.After treatment,the levels of UAR,β2-MG and serum IL-18 NF-a were significantly improved in the two groups.Statistical differences between groups significance（P〈0.05）.Conclusion：Dan shen ligustrazine injection combined with astragalus injection in the treatment of early diabetic nephropathy patients can effectively improve the symptoms of traditional Chinese medicine improve the renal function of patients with lower inflammatory factors in the body the clinical effect is obvious.