摘要
以3-烯烃氧化吲哚为起始原料,甲苯为溶剂,与丙二腈或腈基乙酸乙酯发生区域选择性Michael/Aldol串联反应,合成了6个新型的1'-茚醇拼接3-氧化吲哚类化合物,收率73%~90%,dr高达10/1,其结构经1H NMR,13C NMR和HR-MS(ESI-TOF)表征。
A molecular hybridization strategy has been utilized for the synthesis of novel 1＇-indanolfused 3-oxindoles via a regioselective domino Michael/Aldol reaction of 3-ylideneoxindoles with malononitrile or cyanacetate ethyle,using toluene as the solvent. The yields and dr were 73% ～ 90% and10/1,respectively. The structures were characterized by1 H NMR,13 C NMR and HR-MS（ ESI-TOF）.
作者
刘欢欢
王丹丹
杨楷模
刘雄利
陈琳
余章彪
LIU Huan-huan;WANG Dan-dan;YANG Kai-mo;LIUXiong-li;CHEN Lin;YUZhang-biao(Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center,Guizhou University,Guiyang 550025,Chin)
出处
《合成化学》
CAS
CSCD
北大核心
2018年第6期440-443,共4页
Chinese Journal of Synthetic Chemistry
基金
贵州省科技计划项目(黔科合基础[2017]1035)
贵州省教学改革创新项目(黔教研合JG字[2016]06)
