人牙骨移植材料修复兔胫骨缺损形成新骨的抗压强度

Compressive strength of the newly formed tibia after repair with human tooth bone graft

背景:国外已有将自体牙骨移植材料用于修复牙种植区骨量不足,但形成新骨的强度和质量的研究国内外报道较少。目的:探讨人牙骨移植材料植入兔胫骨缺损形成的新骨的抗压强度。方法:(1)取患者遗弃的完整正畸拔除牙、松动磨牙、双尖牙制备人牙骨移植材料;(2)利用环形骨锯制作2个直径5 mm的胫骨洞穿性骨缺损兔模型,分别设为牙骨移植材料组和牛骨移植材料组,植入人牙骨移植材料和市售牛骨移植材料,以未损伤部位作为对照组。结果与结论:牙骨移植材料组修复兔胫骨缺损形成新骨的显微结构明显比牛骨移植材料组完整,且新骨的最大抗压强度和刚度均大于牛骨移植材料组。说明牙骨移植材料修复兔胫骨缺损形成新骨的效果优于牛骨移植材料。

BACKGROUND： Human tooth bone graft has been used for bone deficiency in dental implantation, but the strength and quality of newly formed bones with human tooth bone graft are in need of sound investigation. OBJECTIVE： To investigate the compressive strength of newly formed rabbit tibia after repair with human tooth bone graft. METHODS： Orthodontic teeth, loose molars, bicuspid premolars extracted from patients were taken to prepare human tooth bone grafts. Human tooth bone graft and bovine bone graft were independently placed into the rabbit tibia defects of 5 mm in diameter. Non-injured site served as control group. RESULTS AND CONCLUSION： The newly formed rabbit tibia after repair with human tooth bone graft had more intact microstructure and higher maximum compressive strength and stiffness relative to that after repair with bovine bone graft. These findings indicate human tooth bone graft is superior to bovine bone graft in the repair of tibia defects in rabbits.