厄贝沙坦氢氯噻嗪联合小剂量甲状腺素治疗老年重症心力衰竭的临床价值

The clinical value of irbesartan hydrochlorothiazide combined with small dose of thyroxine in the treatment of elderly patients with severe heart failure

目的分析厄贝沙坦氢氯噻嗪联合小剂量甲状腺素治疗老年重症心力衰竭的临床效果。方法抽选2015年3月~2017年3月本院收治的68例老年重症心力衰竭患者,依据不同治疗方法为标准分组为实验组和参照组,每组34例。实验组予以厄贝沙坦氢氯噻嗪联合小剂量甲状腺素治疗,参照组予以常规治疗,同时观察、比较两组临床疗效。结果治疗后,实验组有效率94.11%,明显高于参照组的76.47%(P<0.05);实验组T3(1.16±0.11)mmol/L、T4(115.50±1.12)mmol/L、LVEF(54.58±2.50)%水平等改善情况,均优于参照组T3(0.83±0.13)mmol/L、T4(97.65±1.41)mmol/L、LVEF(45.62±1.50)%,差异具有统计学意义(P<0.05)。结论临床对老年重症心力衰竭选厄贝沙坦氢氯噻嗪联合小剂量甲状腺素治疗,疗效比常规治疗方法更高,可在提升治疗有效率的基础上,改善T3、T4、LVEF水平、NYHA心功能分级,具有较高的临床应用价值,可推荐。

Objective To analyze the clinical effect of irbesartan hydrochlorothiazide combined with low dose thyroxine in the treatment of elderly patients with severe heart failure. Methods Selected in March 2015 to March 2017 in our hospital treated 68 cases of elderly patients with severe heart failure, according to the different treatment methods for the standard groups： experimental group and control group, with 34 cases in each group. The experimental group was treated with erbesartan hydrochlorothiazide combined with low dose thyroxine, and the control group was treated routinely, and the clinical efficacy of the two groups was observed and compared, at the same time, observing, comparing two groups of clinical curative effect. Results After treatment, the effective rate of the experimental group was 94.11%, which was significantly higher than 76.47%（P〈0.05）.Experimental group T3（1.16±0.11）mmol/L, T4（115.50±1.12）mmol/L, LVEF（54.58±2.50）% level such as to improve the situation, are better than that of control group T3（0.83±0.13）mmol/L, T4（97.65±1.41）mmol/L, LVEF（45.62±1.50）%, statistically significant difference（P〈0.05）. Conclusion Clinical treatment of severe senile heart failure with erbesartan hydrochlorothiazide combined with low dose thyroxine, curative effect is higher than conventional treatment, can improve treatment in efficient, on the basis of improving level of T3, T4, LVEF and NYHA heart function classification,has high clinical value, can be recommended.