负载吲哚菁绿纳米材料在肿瘤诊断和治疗中的研究进展

Research progress of indocyanine green-loaded nanomaterials in tumor diagnosis and therapy

吲哚菁绿(ICG)是一种生物相容性优良的近红外荧光染料,可应用于肿瘤成像诊断和光热联合治疗等多个领域。但其有限的稳定性、快速代谢性和低细胞摄取率等缺陷限制了它的高效应用。纳米技术的快速发展为此提供了解决平台。负载ICG的多功能纳米材料在控释药物、提高药物生物稳定性、利用度和增强药物输送的靶向性等方面具有诸多优势,在肿瘤早期诊疗领域有较大的应用前景。本文对负载ICG纳米材料性能与特点,及其在肿瘤的多模式成像诊断、联合治疗以及多模式成像指导下的联合治疗方面的最新研究进展作一综述,以期为进一步研究提供参考。

Indocyanine green（ICG） is a biocompatible near-infrared fluorescent dye that can be used in many fields such as tumor imaging and potothermal therapy. But its low stability, rapid metabolism and low cell uptake limited its efficient use. The rapid development of nanotechnology provids a solution platform for this problem. Multifunctional ICG-loaded nanomaterials have many advantages in controlling the release of drugs, improving the biological stability of drugs, enhancing the availability and targeting of drug delivery, etc. It has great application prospect in the field of early diagnosis and treatment of tumor. In this paper, the properties and characteristics of ICG-loaded nanomaterials are summarized, and their latest research progress in the field of multi-modal imaging diagnosis, combined therapy and combined therapy under the guidance of multi-modal imaging application is reviewed.