长期有氧运动联合桂枝茯苓胶囊治疗高血压颈动脉粥样硬化的临床效果

Clinical effect of long-term aerobic exercise combined with Guizhi Fuling Capsules in treatment of carotid atherosclerosis

目的探讨长期有氧运动联合桂枝茯苓胶囊治疗高血压颈动脉粥样硬化的临床疗效。方法选取2016年1月~2017年1月在西安医学院附属医院进行治疗的高血压颈动脉粥样硬化患者186例,按随机数字表法分为对照A组(单纯长期有氧运动治疗)、对照B组(单纯桂枝茯苓胶囊治疗)和试验C组(有氧运动联合桂枝茯苓胶囊综合治疗),每组各62例。观察比较三组患者的血压水平、血脂水平及颈动脉内中膜厚度(CIMT)和斑块面积变化情况。结果治疗后,试验C组患者治疗后的舒张压和收缩压水平均明显低于对照A组和对照B组,差异有统计学意义(P<0.05);试验C组患者治疗后的总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平均明显低于对照A组和对照B组,高密度脂蛋白胆固醇明显高于对照A组和对照B组,差异有统计学意义(P<0.05);试验C组患者的CIMT、斑块面积均明显小于对照A组和对照B组,差异有统计学意义(P<0.05)。结论 长期有氧运动联合桂枝茯苓胶囊治疗高血压颈动脉粥样硬化,能够有效改善患者的血压、脂代谢,并降低患者的颈动脉内中膜厚度、缩小斑块面积,临床效果较为显著。

Objective To explore the clinical efficacy of long-term aerobic exercise combined with Guizhi Fuling Capsules in the treatment of carotid atherosclerosis. Methods From January 2016 to January 2017, in the Affiliated Hospital of Xi′ an Medical University, 186 patients with hypertensive carotid atherosclerosis were selected, according to the random number table method, they were divided into control group A（simple long-term aerobic exercise）, control group B（simple Guizhi Fuling Capsules treatment） and test group C（combined therapy of aerobic exercise and Guizhi Fuling Capsules）, with 62 cases in each group. The blood pressure level, blood lipid level and the thickness of carotid artery（CIMT） and plaque area in the three groups were compared. Results After the treatment, the diastolic pressure and systolic pressure level in test group C were significantly lower than the control group A and the control group B, the differences were statistically significant（P〈0.05）; the levels of total cholesterol, triglyceride and low density lipoprotein in test group C were significantly lower than the control group A and control B group, the high density lipoprotein was significantly higher than the control A group and the control B group, the differences were statistically significant（P〈0.05）; the CIMT and plaque area after treatment in the test group C was significantly smaller than the control group A and control group B, the differences were statistically significant（P〈0.05）. Conclusion The long-term aerobic exercise combined with Guizhi Fuling Capsules can effectively improve the blood pressure and lipid metabolism of the patients, reduce the thickness of the carotid artery and the area of the plaque, and the clinical effect is significant.