舌下含化巯甲丙脯酸在高血压急诊治疗中的临床效果

Clinical effect of sublingual Captopril on the emergency treatment of hypertension

目的研究并探讨舌下含化巯甲丙脯酸在高血压急诊治疗中的临床效果。方法选取2015年1月~2017年12月在我院急诊科就诊的100例高血压患者作为研究对象,在计算机中按照随机数字表法将患者分为两组,每组各50例。对照组患者采用氨氯地平口服治疗,观察组患者在氨氯地平治疗基础上加用巯甲丙脯酸舌下含化治疗。比较两组患者的血压水平、降血压起效时间及不良反应发生情况。结果治疗前,两组患者的收缩压、舒张压比较,差异无统计学意义(P>0.05)。治疗后,两组患者的收缩压、舒张压均低于治疗前,差异有统计学意义(P<0.05),而观察组患者的收缩压、舒张压均低于对照组,差异均有统计学意义(P<0.05)。观察组患者的降血压起效时间为(9.86±2.35)min,短于对照组的(12.75±2.81)min,差异有统计学意义(P<0.05)。观察组患者的不良反应总发生率为8%,对照组为6%,两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在高血压患者急诊治疗期间,采用巯甲丙脯酸舌下含化治疗,可促使患者的血压尽快下降,提高其血压控制效果,且安全性可靠,不会增加用药不良反应风险。

Objective To study and investigate the clinical effect of sublingual Captopril on the emergency treatment of hypertension.Methods A total of 100 hypertensive patients treated in department of emergency in our hospital from January 2015 to December 2017 were selected as subjects and divided into two groups according to the random number table method in the computer,50 cases in each group.The control group was treated with Amlodipine orally,and the observation group was given sublingual therapy with Captopril on the basis of Amlodipine treatment.The blood pressure level,onset time of lowering blood pressure and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in systolic and diastolic pressure between groups（P〉0.05）.After treatment,the systolic pressure and diastolic pressure in the two groups were significantly lower than those before the treatment,the differences were statistically significant（P〈0.05）,while the systolic and diastolic pressure in the observation group were lower than those in the control group,the differences were statistically significant（P〈0.05）.The onset time of lowering blood pressure in the observation group was（9.86±2.35） min,which was shorter than that in the control group of（12.75±2.81） min,the difference was statistically significant（P〈0.05）.The total incidence of adverse reactions was 8% in the observation group,which was 6% in the control group,and the total incidence of adverse reactions in the two groups was not statistically significant（P〉0.05）.Conclusion During the emergency treatment of hypertension,the treatment method of sublingual Captopril can promote the decrease of blood pressure as soon as possible,improve the effect of blood pressure control,and it is safe and reliable,and will not increase the risk of adverse drug reaction.