基于相邻数据依赖性的功能核磁共振混沌分析

Chaotic Analysis of fMRI Based on the Dependence of Neighbor Subseries

为揭示大脑功能活动的非线性特征信息,进而全面揭示大脑内部活动机制,提出一种度量大脑功能活动的相邻数据依赖性(dependence of neighbor subseries,DN)分析方法.采用DN方法分析大脑功能磁共振数据,提取大脑功能活动的非线性特征信息,并将该方法应用于健康男性组与健康女性组大脑功能活动的比较,验证该方法的可行性、有效性.结果表明,较男性健康组,健康女性组在右侧眶部额下回、右侧脑岛、右侧海马、双侧前扣带和旁扣带脑回、左侧内侧额上回、双侧中央前回、双侧中央后回、右侧岛盖部额下回、左侧缘上回的DN值更高,并解释了这些差异可能与大脑结构上及行为和认知上的性别差异有关,通过对比,分析DN方法与局部一致性(regional homogeneity,Re Ho)方法确定的差异区域,发现DN方法可以提取Re Ho方法无法提取的大脑功能活动的非线性特征信息.在一定程度上,这说明将该方法应用于大脑功能活动的研究是可行的、有意义的.

In order to reveal the nonlinear information of brain functional activity,and fully understand the mechanism of brain activity,this study proposed that the dependence of neighbor subseries（DN） analysis method should be used to measure brain functional activity.This study used DN method to explore the brain function activities based on functional magnetic resonance（fMRI）,which could extract the nonlinear characteristics of brain functional activity.In this study,DN was employed to examine the differences of brain function activity between female health group and male health group.The results showed that the DN values of female health group were higher than those of the male health group in the right orbit inferior frontal gyrus,the right insula,the right hippocampus,the bilateral anterior cingulate and paracingulate gyrus,the left medial part of superior frontal gyrus,the bilateral precentral gyrus,the bilateral postcentral gyrus,the right opercular part of the inferior frontal gyrus,the left supramarginal gyrus.The observed differences may be related to sex differences of brain structure and behavior and cognitive.More importantly,the DN method can extract nonlinear characteristics of fMRI that could not be probed by regional homogeneity method.The above results further verified the feasibility and significance of DN analysis of fMRI on a certain degree through comparing the results determined by DN and Re Ho.