大黄提取物对急性肝衰大鼠肝性脑病的防治作用

Preventive and Therapeutic Effects of Extract from Rheum pabnatum on Hepatic Encephalopathy in Rats with Acute Liver Failure

目的:探讨大黄提取物对急性肝衰大鼠肝性脑病的防治作用及其机制。方法:用硫代乙酰胺(TAA)灌胃建立大鼠急性肝衰的肝性脑病模型,观察大黄提取物对肝性脑病大鼠的神经行为改变、神经病学测试、血氨浓度、血浆内毒素浓度和肝脏病理损伤的影响。结果:大黄提取物能明显改善肝性脑病大鼠的神经反射,降低大鼠肝性脑病的分期;显著降低血氨,血浆内毒素浓度,减轻肝脏病理损伤。结论:大黄提取物对TAA引起的大鼠肝性脑病有较好的防治作用,其作用机制与降低血氨、血浆内毒素浓度,保护肝细胞有关。

Objective: To probe the preventive, therapeutic effect and the possible mechanism of extract from Rheum palmatum ( ERP) on hepatic encephalopathy(HE) in rats with acute liver failure. Methods: HE was induced by the administration of 300 mg thioracetamide per kg body weight by gavage on two consecutive days. The effects of ERP were observed on neurology test, serum ammonium, serum endotoxin and liver impairment. Results: ERP could improve rat neuro-reflexes, decrease the staging of HE and rat serum ammonium, endotoxin concentrations, and reduce the liver impairment. Conclusion: ERP significantly prevents and treats HE in rats with thioacetamide-induced acute liver failure.