山东蒙脱石与思密达止泻作用的比较研究

Comparative Study between Montmorillonite and Smecta on Anti-dysentery Effect

目的:比较山东产蒙脱石与思密达(smecta)的止泻作用功效。方法:实验对用硫酸镁、大黄粉、蓖麻油制成小鼠腹泻模型分别给予15.6％、31.2％蒙脱石、31.2％思密达,观察蒙脱石和思密达对模型小鼠胃肠推进速度及腹泻次数的影响;给予家兔空肠局部0.2％乙酰胆碱50 μl,观察国产蒙脱石和思密达对其所致空肠过度收缩的影响。结果:实验结果表明,山东蒙脱石和思密达均能显著地降低硫酸镁和大黄粉所致的胃肠过度运动的推进速度,降低腹泻次数;抑制乙酰胆碱所致的小肠过度收缩。结论:山东蒙脱石在相同剂量下,其止泻药效作用与法国进口药思密达相同,可有效地吸附肠内有害物质,是一具有较好前景的止泻中药。

Objective: To compare the efficiency of montmorillonite (Mengtuoshi) and Smecta. Methods: The effects on the dysentery mice induced by MgSO4, rhubarb powder and castor oil, were observed by given respectively 15.6% , 31.2% Mengtuoshi and 31.2% Smecta. And the effects on the over-contracted rabbit intestines were also observed. Results: Both Mengtuoshi and Smecta could relieve the over pushing speeding of stomach and intestine, and reduce the times of dysentery. Conclusion: The anti-dysentery effect of Mengtuoshi was similar to Smecta from France and may be used as good anti-dysentery drug.