CITED2在乳腺癌组织中的表达及其意义

CITED2 expression in breast carcinoma and its significance

目的:探讨CITED2蛋白在乳腺癌组织中的表达情况及与临床病理特征的关系。方法:应用免疫组化染色方法检测128例乳腺癌组织中CITED2蛋白的表达,应用Pearson相关分析检测其与乳腺癌临床病理特征的相关性。结果:乳腺癌组织中CITED2蛋白的表达明显高于正常乳腺组织。CITED2的表达水平与乳腺癌组织学分级呈正相关,与ER及PR的表达呈负相关,与HER2的扩增呈正相关,与Ki-67增殖指数呈正相关,CITED2与淋巴结转移相关,与患者年龄、肿瘤体积等无明显相关性。结论:CITED2的表达与乳腺浸润性导管癌的恶性程度呈正相关,并且不同免疫表型的乳腺癌组织中CITED2蛋白也有差异,这为临床乳腺癌患者的预后预测及治疗提供了新的靶点和理论依据。

Objective ：To evaluate CITED2 expression in invasive breast carcinoma and elucidate the association with clinicopathological features. Methods ：128 cases of invasive breast carcinoma were immunohistochenfically ana- lysed with CITED2 protein. The associations between CITED2 expression and clinicopathologic features of the patients with breast carcinoma were analyzed using Pearson~ chi - square test. Results ： CITED2 expression was higher than that in normal breast tissue. CITED2 expression was positively related to the histologic grading of breast carcinoma. In- versely related with ER and PR expression, positively related to HER2 amplification, positively related to Ki -67 pro- liferation index,related to lymph node metastasis,but have no correlation with age and tumor size. Conclusion： CIT- ED2 expression was positively related to the malignancy of breast invasive ductal carcinoma and its expression was va- riant in different imnmnophenolypes of breast carcinoma, which provide a new indicator for prognosis and a new target for treatment of breast carcinoma.