连续性血液透析与间歇性血液透析治疗急性肾衰竭的效果观察

Observation of effect on continuous hemodialysis and intermittent hemodialysis in the treatment of acute renal failure

目的观察连续性血液透析与间歇性血液透析治疗急性肾衰竭的效果。方法 40例急性肾衰竭患者,依据治疗方法不同分为连续性血液透析组和间歇性血液透析组,各20例。连续性血液透析组患者接受连续性血液透析治疗,间歇性血液透析组患者接受间歇性血液透析治疗,对两组患者的肾功能指标水平、急性生理学及慢性健康状况评分Ⅱ(APACHE-Ⅱ)评分以及低血压、心律失常发生次数进行对比。结果治疗前,两组血肌酐(Scr)、尿素氮(BUN)水平及APACHE-Ⅱ评分比较差异无统计学意义(P>0.05);治疗后,两组Scr、BUN水平及APACHE-Ⅱ评分均显著降低,且连续性血液透析组患者的降低幅度显著高于间歇性血液透析组,差异均具有统计学意义(P<0.05)。连续性血液透析组患者的低血压、心律失常发生次数分别为(1.7±0.5)、(1.2±0.4)次,均显著少于间歇性血液透析组的(3.9±1.3)、(3.7±1.6)次,差异均具有统计学意义(P<0.05)。结论连续性血液透析治疗急性肾衰竭的效果较间歇性血液透析好,值得在临床推广应用。

Objective To observe the effect of continuous hemodialysis and intermittent hemodialysis in the treatment of acute renal failure. Methods A total of 40 acute renal failure patients were divided by different treatment methods into continuous hemodialysis group and intermittent hemodialysis group, with 20 cases in each group. Continuous hemodialysis group received continuous hemodialysis for treatment, and intermittent hemodialysis group received intermittent hemodialysis for treatment. Comparison were made on renal function index, acute physiology and chronic health evaluation Ⅱ（APACHE-Ⅱ） score, and the frequency of hypotension and arrhythmia between the two groups. Results Before treatment, both groups had no statistically significant difference in serum creatinine（Scr）, blood urea nitrogen（BUN） level and APACHE-Ⅱ score（P〉0.05）. After treatment, both groups had obviously lower Scr、BUN and APACHE-Ⅱ score, and continuous hemodialysis group had obviously higher decline range than intermittent hemodialysis group. Their difference was statistically significant（P〈0.05）. Continuous hemodialysis group had obviously less frequency of hypotension and arrhythmia respectively as（1.7±0.5） and（1.2±0.4） times than（3.9±1.3） and（3.7±1.6） times in intermittent hemodialysis group, and the differences were statistically significant（P〈0.05）. Conclusion Continuous hemodialysis shows better effect than intermittent hemodialysis in the treatment of acute renal failure, and it is worthy of clinical promotion and application.