左氧氟沙星与莫西沙星治疗耐药性肺结核的临床效果

Clinical effect of Levofloxacin and Moxifloxacin in the treatment of drug-resistant pulmonary tuberculosis

目的观察左氧氟沙星与莫西沙星治疗耐药性肺结核的临床效果。方法 166例耐异烟肼肺结核患者,采取数字表随机法分为左氧氟沙星组和莫西沙星组,每组83例。左氧氟沙星组采取左氧氟沙星治疗,莫西沙星组采取莫西沙星治疗,比较两组临床效果。结果左氧氟沙星组总有效率为69.88%,莫西沙星组总有效率为86.75%,左氧氟沙星组患者总有效率低于莫西沙星组,差异具有统计学意义(P<0.05)。左氧氟沙星组患者治疗3、6、12个月的痰菌转阴率均低于莫西沙星组,差异均具有统计学意义(P<0.05)。左氧氟沙星组不良反应发生率26.51%,莫西沙星组不良反应发生率12.05%,左氧氟沙星组患者不良反应发生率高于莫西沙星组,差异具有统计学意义(P<0.05)。结论莫西沙星治疗耐药性肺结核的临床效果显著,较左氧氟沙星更好,对患者有利。

Objective To observe the clinical effect of Levofloxacin and Moxifloxacin in the treatment of drug-resistant pulmonary tuberculosis. Methods A total of 166 patients with drug-resistant pulmonary tuberculosis were divided by random number table method into levofloxacin group and moxifloxacin group, with 83 cases in each group. Levofloxacin group was treated with levofloxacin group, and moxifloxacin group was treated with moxifloxacin. The clinical effect in two groups was compared. Results Levofloxacin group had total effective rate as 69.88%, which was 86.75% in Moxifloxacin group. Levofloxacin group had lower total effective rate than Moxifloxacin group, and the difference was statistically significant（P〈0.05）. Levofloxacin group had lower sputum negative-conversion rate of after 3, 6 and 12 months of treatment than Moxifloxacin group, and the difference was statistically significant（P〈0.05）. Levofloxacin group had incidence of adverse reactions as 26.51%, which was 12.05% in Moxifloxacin group, and the difference was statistically significant（P〈0.05）. Conclusion Moxifloxacin shows better clinical effect than Levofloxacin in the treatment drug-resistant pulmonary, and it is beneficial to the patients.