间苯三酚治疗体外受精-胚胎移植助孕后阴道流血患者的临床研究

Clinical study of phloroglucinol on treatment of vaginal bleeding after in-vitro fertilization and embryo transfer

目的研究间苯三酚在体外受精-胚胎移植助孕后出现阴道流血患者的治疗作用。方法选取2015-01~2017-01该院行体外受精-胚胎移植助孕后获得宫内临床单胎妊娠,且在孕12周之前出现阴道流血及伴有腹痛症状的患者为研究对象。纳入研究对象的患者共计84例,随机分为对照组和研究组各42例。对照组实行单纯黄体支持用药方案。研究组在黄体支持用药的同时给予间苯三酚注射液治疗。观察比较两组患者阴道流血改善情况、腹痛症状缓解情况、不良反应发生情况和患者妊娠结局(包括两组患者的流产率、活产率及新生儿畸形率)等情况。结果研究组患者腹痛缓解及阴道流血情况改善明显,与对照组比较差异均有统计学意义(P<0.05),且无不良反应发生;两组的流产率、活产率比较差异均无统计学意义(P>0.05),两组均无畸形儿出生。结论间苯三酚可以有效地改善体外受精-胚胎移植助孕后阴道流血患者的症状,安全有效。

Objective To study the clinical effectiveness of phloroglucinol in treatment of vaginal bleeding after in-vitro fertilization and embryo transfer. Methods 84 patients suffered from vaginal bleeding and abdominal pain after in-vitro fertilization and embryo transfer were collected in the People＇s Hospital of Guangxi Zhuang Autonomous Region from January 2015 to January 2017 and were randomly divided into the control group and the research group,with 42 cases in each group. The patients in the control group were treated with progesterone alone,and those in the research group were treated with progesterone and phloroglucinol simultaneously. The adverse reactions,the improvements of clinical symptoms such as vaginal bleeding and abdominal pain were observed and compared between the two groups. The pregnancy outcomes such as abortion rate,live birth rate and neonatal malformation rate were compared between the two groups. Results The improvements of vaginal bleeding and abdominal pain in the research group were better than those in the control group（ P〈0. 05）. No adverse reactions were observed in both of the two groups. There were no significant differences in the abortion rate and live birth rate between the two groups（ P〈0. 05）. The malformed newborn was not founded in both of the two groups. Conclusion Phloroglucinol is safe and effective in improving the clinical symptoms of vaginal bleeding after in-vitro fertilization and embryo transfer.