奎硫平与利培酮治疗高龄老年人脑血管病所致精神障碍的疗效研究

The Efficacy and Safety of Quetiapine and Risperidone in the Treatment of Mental Disorders Caused by Cerebrovascular Disease in the Elderly

目的探讨奎硫平与利培酮治疗高龄老年人脑血管病所致精神障碍的疗效及安全性。方法选择2016年5月~2017年5月期间本院收治的106例高龄老年人脑血管病所致精神障碍患者作为研究对象,依据随机数字抽取表法对患者进行分组,每组各53例,A组采用奎硫平治疗,B组采用利培酮治疗,比较两组患者治疗效果及安全性。结果 A组治疗有效率(90.56%)与B组治疗有效率(71.69%)相比明显更高,差异具有统计学意义(P<0.05);A组患者兴奋、失眠、嗜睡、肝功能异常、椎体外系反应、肌强直等不良反应发生率(16.98%)显著低于B组(43.39%),差异具有统计学意义(P<0.05)。结论对高龄老年人脑血管所致精神障碍患者采用奎硫平治疗效果优于利培酮,且在保证疗效的前提下降低不良反应,安全性好,临床应用价值较高。

Objective To investigate the efficacy and safety of quetiapine and risperidone in the treatment of senile cerebrovascular disease caused by mental disorder. Methods 106 cases of patients with mental disorders caused by cerebrovascular disease in the elderly in our hospital from May 2016 to May 2017 were selected and divided into group A and group B according to random numbers method, with 53 cases in each group. The patients in the group A received quetiapine treatment, and the patients in the group B received risperidone treatment. The efficacy and safety of the two groups were compared. Results The effective rate of treatment in group A was 90.56%, which was significantly higher than that of group B, and the difference was statistically significant（P 0.05）. The occurrence rate of adverse reactions such as excited, insomnia, drowsiness, abnormal liver function, extrapyramidal reactions, myotonia in A group were 16.98%, which was significantly lower than that of group B（43.39%）.The difference was statistically significant（P 0.05）. Conclusion For patients with mental disorders caused by senile cerebral vascular, the curative effect of quetiapine was superior to risperidone. Under the premise of guaranteeing the curative effect, the adverse reaction of quetiapine was reduced, the safety was good, and the clinical application value was high.