miR-497-5p在子宫内膜病变组织中的表达及临床意义

Expression of miR-497-5p in Endometrial Lesions and Its Clinical Significance

目的检测mi R-497-5p在不同子宫内膜病变组织中的表达,探讨与子宫内膜癌临床病理参数的关系及其临床意义。方法采用原位杂交法检测110例子宫内膜癌、20例非典型增生及30例正常子宫内膜组织中miR-497-5p的表达。结果子宫内膜癌及非典型增生子宫内膜组织中,mi R-497-5p的阳性表达率均低于正常内膜组织,其表达强度与临床分期(P<0.001)、分化级别(P<0.001)、肿瘤浸润深度(P=0.039)和淋巴结转移(P=0.022)有关。利用癌症和肿瘤基因图谱数据库中数据进行生存分析,提示mi R-497-5p高表达组子宫内膜癌患者预后更佳(P<0.05)。结论 mi R-497-5p在子宫内膜癌组织中的表达水平明显降低,可作为判断子宫内膜癌患者预后的指标之一。

Objective To investigate mi R-497-5 p expression in different endometrial lesions,determine its relationship with clinicopathological parameters,and explore its clinical significance. Methods mi R-497-5 p expression in 110 cases of endometrial carcinoma,20 cases of atypical endometrial hyperplasia,and 30 normal endometria was detected by in situ hybridization. Results The frequency of positive mi R-497-5 p expression was lower in endometrial carcinoma and atypical hyperplasia than in normal endometrial tissues. mi R-497-5 p expression was associated with the clinical stage（P〈0.001）,differentiation level（P〈0.001）,tumor invasion depth（P=0.039）,and lymph node metastasis（P= 0.022）. Survival analysis conducted on data from the TCGA database revealed a better prognosis of patients with endometrial cancer overexpressing mi R-497-5 p（P〈0.05）. Conclusion mi R-497-5 p expression is significantly decreased in endometrial carcinoma tissues,indicating its utility as a prognostic marker in patients with endometrial cancer.