稳心颗粒联合美托洛尔治疗冠心病室性心律失常的Meta分析

Wenxin Granules Combined with Metoprolol in the Treatment of Coronary Heart Disease with Ventricular Arrhythmias:A Meta-analysis

目的系统评价稳心颗粒联合美托洛尔治疗冠心病室性心律失常的临床疗效及安全性。方法计算机检索Pud Med、Cochrane、中国生物医学文献数据库(CBM)、维普、万方和中国知网(CNKI),收集从建库至2017年12月关于稳心颗粒联合美托洛尔干预冠心病室性心律失常的临床随机对照试验(RCT),按纳入和排除标准由两名研究员独立完成文献的质量评价及资料提取,采用Rev Man 5.3软件进行Meta分析。结果共纳入31个RCT,共3 075例患者,稳心颗粒联合美托洛尔组在临床总有效率、心电图有效率、ST段压低幅度、ST段下移持续时间、室早次数、短阵室速阵数、不良反应发生率方面,其疗效均优于对照组,差异有统计学意义(P<0.05)。结论治疗冠心病室性心律失常,稳心颗粒联合美托洛尔与单用美托洛尔相比,其临床疗效更加显著,安全性更高。

Objective To evaluate the clinical efficacy and safety of Wenxin granules combined with metoprolol in the treatment of coronary heart disease with ventricular arrhythmia. Methods We searched the PudMed, Cochrane library, China Biology Medicine disc （CBMdisc）, Chinese VIP database, Wanfang database and CNKI database （CNKI）, and collected the clinical randomized controlled trials （RCT） before August 2017 on the intervention of Wenxin Granule combined with metoprolol in treatment of coronary heart disease with ventricular arrhythmia. The data were screened by two researchers independently according to inclusion and exclusion criteria, using the software Revman 5.3 for meta-analysis. Results A total of 31 RCTs （3075 cases） were included. The total clinical efficiency, the efficiency of ECG, ST segment depression, ST segment duration, ventricular premature beat number, nonsustained ventricular tachycardia array, the incidence rate of adverse reaction in Wenxin grnules group were significantly better than those in the control group （P〈0.05）. Conclusion The clinical effect of Wenxin granules combined with metoprolol is more significant than that of Metoprolol alone in the treatment of coronary heart disease with ventricular arrhythmia.