中药提取物改善多囊卵巢综合征中胰岛素抵抗的研究进展

Research Progress in Improvement of Polycystic Ovary Syndrome with Insulin Resistance by Traditional Chinese Herb Extracts

多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是一组以无排卵或稀发排卵、不孕、高雄激素血症等为主要表现的异质性内分泌疾病。胰岛素抵抗(insulin resistance,IR)不仅是PCOS的重要内分泌表现,同时也是其可能发病机制之一。近年来黄连素(berberine,BBR)、葛根素(puerarin)、隐丹参酮(cryptotanshintone)、甘草次酸(glycyrrhetinic acid)等中药提取物在PCOS患者中IR的疗效受到了广泛关注。大量研究表明中药提取物可通过腺苷酸活化蛋白激酶(adenosine 5′-monophosphate-activated protein kinase,AMPK)、丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)等多种途径有效改善PCOS患者IR情况。综述中药提取物在PCOS治疗中改善IR的可能机制。

Polycystic ovarian syndrome（PCOS） is a group of heterogeneous endocrine diseases which is characterized by oligoovulatory and anovulatory, infertility, hyperandrogenism and so on. Insulin resistance（IR） is an important endocrine manifestation of PCOS, besides it is also one of the possible pathogenesis of PCOS. Recently berberine（BBR）, puerarin,cryptotanshintone, glycyrrhetinic acid and other traditional Chinese herb extracts have attracted widespread attention in the treatment of IR in PCOS patients. A large number of studies show that the mechanism includes adenosine 5 ′-monophosphateactivated protein kinase（AMPK）, mitogen-activated protein kinase（MAPK） and so on. This article is a review of the possibly mechanism about traditional Chinese herb extracts in the improvement of PCOS with insulin resistance.