江苏地区5028例肾活检病理类型与甲状腺疾病关系分析

Analysis of the relationship between renal pathological patterns and thyroid diseases in 5028 cases of renal biopsy in Jiangsu province

目的:初步探讨江苏地区5 028例肾活检标本病理类型与甲状腺疾病的关系。方法:回顾性分析东南大学附属中大医院肾脏病研究所行病理诊断的5 028例肾活检标本的临床和病理资料。结果:5 028例肾穿病例中,合并甲状腺疾病者89例,女性占76.41%;甲状腺机能减退在伴发的3种甲状腺疾病中占64%;89例甲状腺疾病与12种肾脏疾病伴发,其中狼疮性肾炎、干燥综合征肾损伤、混合性结缔组织病性肾损伤等自身免疫性疾病伴发率较其他肾脏病为高;甲状腺疾病伴发率在全部肾穿刺标本中或膜性肾病中均有逐年升高趋势。结论:肾穿刺病例中,合并甲状腺疾病以女性、甲状腺机能减退多见;自身免疫性肾脏疾病常伴发甲状腺疾病;肾脏疾病伴发甲状腺疾病逐年增多,应予重视。

Objective： To analyze the relationship between thyroid diseases and pathological patterns in 5 028 cases of renal biopsy in Jiangsu province. Methods： We retrospectively analysed the clinicopathological data of 5 028 cases undergoing percutaneous renal biopsy. Results： In the 5 028 renal patients 89 cases coexisted with thyroid diseases and females accounted for 76. 41%. Hypothyroidism accounted for 64% in the three kinds of thyroid diseases. Eighty-nine cases of thyroid disease coexisted with 12 kinds of renal diseases,of which the incidence of coexistence in autoimmunne kidney diseases,such as lupus nephritis,Sjogren syndrome and mixed connective tissue disease,was higher than that of other kidney diseases. There was a yearly increasing tendency of all kidney diseases or membranous nephropathy coexisting with thyroid diseases. Conclusion： The female and hypothyroidism patients of thyroid diseases are commonly found in the renal biopsy. Patients with autoimmune kidney diseases are often complicated with thyroid diseases. It is necessary to pay close attention to the increasing tendency of the coexistence of renal disease and thyroid disease.