口腔癌动物模型研究进展

Advances in research on animal models of oral cancer

口腔癌严重威胁人类的健康和生活,而且发病率也逐年增高。应用口腔癌动物模型进行临床口腔癌的诊断和治疗研究,具有不可替代的作用。因此,建立与人类口腔癌自然发生较为相似的疾病动物模型并进行致病机理、预防和治疗等方面的研究十分重要。目前,口腔癌动物模型主要有自发性动物模型、诱发性动物模型和基因修饰动物模型。本文总结概括了近年来口腔癌动物模型的研究进展、目前面临的问题以及今后的发展前景。

Oral cancer is not only a serious threat to human health and life but also its incidence rate has beenincreasing year by year. Oral cancer animal model is indispensable for the research of clinical diagnosis and treatment of oralcancer. Therefore, it is of great importance to establish an animal model of disease which is similar to the natural occurrenceof human oral cancer and to study its pathogenesis, prevention and treatment. At present, animal models of oral cancermainly include spontaneous animal model, induced animal model and genetically modified animal model. The researchprogress, current problems and the future development perspectives of animal models of oral cancer in recent years aresummarized in this paper.