HIV潜伏库治疗策略研究

Research on the strategy of eradication of HIV latent reservoirs

HIV潜伏库是指在免疫反应和抗病毒治疗压力下,HIV潜伏的细胞和组织。尽管高效抗逆转录病毒疗法(HAART)的出现,有效地控制了HIV感染,使得血浆中的病毒载量抑制在低水平或检测线以下,但是却不能彻底清除潜伏库中的病毒,一旦停止抗病毒治疗,即发生病毒反弹。因此,清除潜伏于宿主体内的HIV是根治艾滋病的重大挑战。本文将对近年来艾滋病潜伏库的治疗策略做一综述。

HIV latent reservoirs are the latent cells and tissues of HIV under the pressure of immune responses andantiviral therapy. Although HIV infection is effectively controlled by the advent of highly active antiretroviral therapy（HAART） and the viral load in the plasma is suppressed to a low level which are undetectable by most clinical measures,HAART is not able to completely eradicate the virus in the reservoirs. The viral rebound occurs when antiviral therapy isceased. Therefore, the eradication of HIV reservoirs is a major challenge for the therapy of AIDS. In this paper, we willfocus on the strategies of eradication of AIDS latent reservoirs.