粉防己碱治疗肺纤维化作用机制及应用进展

Pharmacological research and application progress of tetrandrine in treating idiopathic pulmonary fibrosis

肺纤维化(PF)是各种间质性肺疾病晚期的共同结局,目前尚没有有效的治疗方法。粉防己碱为汉防己的主要有效成分之一,在矽肺的治疗方面已经显示出良好的抗纤维化作用,且价格低廉、不良反应少。本文通过复习文献,总结了粉防己碱抗纤维化的主要作用机制包括:抑制炎症反应、改善氧化应激、影响细胞凋亡、干预转化生长因子β(TGF-β)的表达;并对近年来粉防己碱治疗特发性PF的临床报道进行介绍,为粉防己碱治疗特发性PF的临床应用提供理论依据。

Pulmoary fibrosis is the final outcome for a variety of interstitial lung disease,and there is no effective treatment. Tetrandrine（Tet） is the main alkaloid isolated from the lumpy root of Stephania tetrandra,and has shown good anti-fibrosis effect in the treatment of silicosis, with low price and few side effects. this paper is intended to summarize the main mechanism of tetrandrine anti-fibrosis,including： uppressing inflammatory reaction; improving oxidative stress; affecting cell apoptosis; interventing the expression of TGF-β1. meanwhile, the clinical reports of tetrandrine in the treatment of idiopathic pulmonary fibrosis in recent years were introduced, which provided theoretical basis for clinical application.