低浓度氯气诱导大鼠喉部损伤及地塞米松治疗效果

The low concentration of chlorine induced laryngeal injury and dexamethasone treatment

目的:观察低浓度氯气吸入后大鼠喉部损伤及地塞米松的治疗效果。方法:大鼠置于浓度为50 ppm氯气容器罐中15 min,喉镜观察大鼠喉部的损伤,病理检查喉部组织学改变,评估即刻地塞米松治疗后的效果。结果:大鼠吸入低浓度氯气后喉部出现炎性水肿渗出损伤改变,即刻地塞米松治疗后,喉部粘膜水肿消退明显,分泌物明显减少,病理示被覆鳞状上皮完整,细胞形态大小正常,表面未见有炎性渗出,无出血,粘膜下固有层未见明显水肿,软骨形态正常,未见粘液变性。结论:早期给予地塞米松治疗可有效缓解较低浓度氯气吸入后导致的喉部损伤。

Objective： To investigate the inflammatory changes of laryngeal injury in rats after inhaling the low concentration of chlorine. To explore the therapeutic effect of laryngeal injury by dexamethasone. Methods：To observe the fibrolaryngoscope and the pathological changes of larynx in rats after 15 minutes in the chlorine tank with the concentration of 50 PPM. The changes of laryngeal were observed after withdrawal of chlorine treated by dexamethasone（100 mg/kg） immediately. Results：The low concentration of chlorine inhalation could induce the inflammatory edema and exudation of larynx in rats. After being treated by dexamethasone, Laryngeal mucosa edema subsided significantly, and secretion decreased significantly. Covered squamous epithelium was integrated, The shape and the size of cells were normal.There was no inflammatory exudate on the surface, or no bleeding. There was not any submucosal lamina propria edema.Cartilage morphology was normal, and there was not mucous degeneration. Conclusion：Dexamethasone can effectively alleviate the laryngeal damage caused by low concentration of chlorine at the early stage.