针刺联合注射用唑来膦酸干预乳腺癌骨转移患者疼痛的临床研究

Intervention of Acupuncture Combined with Zoledronic Acid Injection on Pain due to Breast Cancer with Bone Metastases:A Clinical Study

观察针刺攒竹、太溪穴对乳腺癌骨转移患者疼痛、活动能力及血清β-内啡肽(β-EP)含量的影响,探讨针刺对乳腺癌骨转移患者疼痛的影响和调节作用。方法:将60名患者随机分为治疗组、对照组,每组各30例。治疗组静脉滴注唑来膦酸配合针刺攒竹、太溪穴治疗,对照组静脉滴注唑来膦酸治疗,通过放免法检测血清β-EP含量并评价疗效。结果:两组分别在治疗24 h、2个月后的VAS评分、ECOG评分均有显著降低(均P<0.05),且治疗组在治疗后18 min评分显著降低(P<0.05);两组治疗2个月后的β-EP水平均有显著降低(P均<0.05),治疗组在治疗后18 min、24 hβ-EP水平出现显著降低(P<0.05);两组临床疗效比较,治疗组治疗总有效率显著高于对照组(P<0.05)。结论:针刺联合唑来膦酸注射液治疗乳腺癌骨转移可显著提高唑来膦酸注射液临床疗效,改善患者生活能力;可抑制因乳腺癌骨转移疼痛被激活的β-EP,提高患者的生活质量。

Objective： To observe the effect of needling Cuanzhu（ BL2） and Taixi（ KI3） on pain relief,mobility,and serum content of β-endorphin（ β-EP） in breast cancer patients with bone metastases,and to discuss the pain regulation of acupuncture. Methods： 60 patients were randomly divided into the treatment group（ n =30） and the control group（ n = 30）. The control group was given Zoledronic Acid injection; on which basis,the trentment group was also treated with needling points of BL2 and LI3. Serum content of β-EP was detected by radioimmunoassay method to assess the effect. Results： Scores of VAS and ECOG were significantly decreased24 hours after treatment and after two months of treatment in the two groups（ P〈0. 05）; and the scores were decreased more significantly 18 minutes after treatment in the treatment group（ P〈0. 05）. The content of β-EP were also significant decreased after two months of treatment（ P〈0. 05）; it was decreased more significantly18 min after treatment and 24 h after treatment in the treatment group（ P〈0. 05）. The total effective rate of the treatment group was obiously higher than that of the control group（ P〈0. 05）. Conclusion： Acupuncture combined with Zoledronic Acid injection can significantly improve the clinical curative effect,improve the life ability of the patients. The therapy can inhibit the activated β-EP due to pain in breast cancer patients with bone metastases to improve their life quality.