2-氨基噻二唑的合成及工艺优化

Synthesis of 2-Aminothiadiazole Optimization

以取代苯甲酸和氨基硫脲为原料,在三氯氧磷作氯化试剂条件下合成氨基噻二唑类衍生物,并且探究工艺条件对产率的影响。实验表明,最佳合成工艺为:三氯氧磷10mL,反应温度85℃,反应时间为6h,产率均在80%以上。所有化合物的结构经~1H NMR和IR表征。

Substituted benzoic acid derivatives and thiosemicarbazide as raw materials, with phosphorusoxychloride as chlorination reagent, synthesis of aminothiadiazole derivatives, and to explore the impact of process conditions on the yield.Experiments show that the best synthesis process is： POCl_3 10 mL, 85℃, 6 h, yields were above 80%. All the synthesized compounds were characterized on the basis of their IR,~1 HNMR and mass spectral data.