摘要
以取代苯甲酸和氨基硫脲为原料,在三氯氧磷作氯化试剂条件下合成氨基噻二唑类衍生物,并且探究工艺条件对产率的影响。实验表明,最佳合成工艺为:三氯氧磷10mL,反应温度85℃,反应时间为6h,产率均在80%以上。所有化合物的结构经~1H NMR和IR表征。
Substituted benzoic acid derivatives and thiosemicarbazide as raw materials, with phosphorusoxychloride as chlorination reagent, synthesis of aminothiadiazole derivatives, and to explore the impact of process conditions on the yield.Experiments show that the best synthesis process is: POCl_3 10 mL, 85℃, 6 h, yields were above 80%. All the synthesized compounds were characterized on the basis of their IR,~1 HNMR and mass spectral data.
作者
王伟
王莉
褚明杰
WANG Wei;WANG Li;CHU Ming-jie(School of Science,Anhui Agricultural University,Hefei 230036,China)
出处
《安徽化工》
CAS
2018年第3期30-31,36,共3页
Anhui Chemical Industry
基金
应用化学专业安徽久易农业股份有限公司实践教育基地项目
关键词
三氯氧磷合环法
氨基噻二唑
合成
phosphorus oxychloride ring method
aminothiadiazole
synthesis