一种新型PLGA/鱼皮胶原共轭静电纺丝膜的物理性能研究

Physical properties study of a new type of PLGA/fish skin collagen conjugate electrostatic spinning film

目的 :研究一种新型聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]/鱼皮胶原共轭静电纺丝膜的物理性能。方法:制备PLGA电纺膜(A组)、纯鱼皮胶原膜(B组)及新型PLGA/鱼皮胶原共轭静电纺丝膜(C组)3种膜,分别检测接触角、失重率、拉伸强度、断裂伸长率等物理性能,初步评价新型PLGA/鱼皮胶原共轭静电纺丝膜的物理性能,为其应用于种植引导组织再生提供理论依据。结果:新型PLGA/鱼皮胶原共轭静电纺丝膜(C组)具有良好的亲水性,接触角为68.52°;体外降解12周后失重率为(14.85±0.13)%,拉伸强度为(2.41±0.47)MPa,断裂伸长率为(77.98±25.72)%,失重率速率最小且仍保持一定的拉伸强度与断裂伸长率。结论 :PLGA/鱼皮胶原共轭静电纺丝膜的物理机械性能能够达到临床要求,为进一步的细胞实验提供基础。

Objective： To study the physical properties of a new poly（lactic-co-glycolic acid）（PLGA）/fish collagen conjugated electrostatic spinning film. Methods： The physical properties of PLGA electrospinning film（group A）, pure fish collagen film（group B） and new PLGA/fish collagen conjugated electrostatic spinning film（group C） were studied, such as contact angle, loss of weight, tensile strength and elongation. Results： The new PLGA/fish collagen conjugated electrostatic spinning film has good hydrophilicity, contact angle is 68.52°. 12 weeks after in vitro degradation of weightlessness rate was（14.85±0.13）%, the tensile strength was（2.41±0.47） MPa and elongation at break was（77.98±25.72）%, the minimum rate of weightlessness rate and still maintain a certain tensile strength and elongation at break. Conclusion： The physical and mechanical properties of PLGA/fish collagen conjugated electrostatic spinning film can meet the clinical requirements and provide the basis for further cell experiments.