慢性期男性精神分裂症患者血清IL-6、IL-10与社会功能的关联研究

Association of serum IL-6, IL-10 and social function in men patients with chronic schizophrenia

目的 :探讨慢性期男性精神分裂症患者血清白细胞介素(interleukin,IL)-6、IL-10水平与社会功能状况,以及它们之间的相关性。方法:选取无锡市精神卫生中心慢性期男性精神分裂症患者62例和正常对照60例,采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评估患者的精神症状;采用住院精神病患者社会功能评定量表(scale of social function in psychosis in patients,SSPI)和社会适应量表(social-adaptive functioning evaluation,SAFE)评定患者的社会功能。使用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测所有受试者的血清IL-6、IL-10水平。结果:精神分裂症组血清IL-6水平高于正常对照组(P<0.05),血清IL-10水平低于正常对照组(P<0.01)。精神分裂症组IL-10与SSPI量表得分呈正相关(r=0.23,P=0.01),与SAFE量表得分呈负相关(r=-0.20,P=0.04),与PANSS量表阴性症状分呈负相关(r=-0.22,P=0.02);IL-6与社会功能、PANSS量表无相关性。结论:慢性期男性精神分裂症患者存在免疫功能异常,而IL-10可能是精神分裂症社会功能的一种潜在的生物学指标。

Objective： To investigate the levels of serum interleukin（IL）-6, IL-10 and social function in male patients with chronic schizophrenia, and their inter-correlation. Methods： Sixty-two male patients with chronic schizophrenia and 60 normal controls were selected as the research object from our hospital. Positive and negative syndrome scale（PANSS） was adopted by evaluating the patients ′ psychiatric symptoms. Scale of social function in psychosis in patients（SSPI） and social-adaptive functioning evaluation（SAFE） were used for assessing the patient′s social function. The serum IL-6 and IL-10 levels of all the subjects were detected by enzyme linked immunosorbent assay（ELISA）. Results： Serum IL-6 levels in the schizophrenia group were higher than those in the normal control group（P〈0.05）. Serum IL-10 levels were lower in the schizophrenia group than those in the normal control group（P〈0.01）. In schizophrenia group, IL-10 were positively correlated with SSPI score（r=0.23,P=0.01）, negatively correlated with SAFE scale（r=-0.20, P=0.04）, and negatively correlated with negative scores of PANSS scale（ r =-0.22, P=0.02）. There was no correlation between the IL-6 and the social function and the PANSS scale in the schizophrenia group. Conclusion： Schizophrenia in chronic stable male patients has abnormal immune function, and IL-10 may be a potential biological indicator of schizophrenia′s social function.