Peyronie病发病机制研究进展

Research progress in the pathogenesis of Peyronie′s disease

Peyronie病(Peyronie′s disease,PD)又称阴茎海绵体硬结症,是一种局部结缔组织病,本病特点是在阴茎海绵体白膜内和勃起组织中形成纤维斑块。这些斑块含有较多的胶原和增生的弹性纤维组织,导致阴茎不同程度的弯曲和缩窄,造成阴茎疼痛及勃起功能障碍(erectile dysfunction,ED)。目前发病机制尚不明确,且关于该病的治疗仍存在一些争议。PD的发病机制已经在动物模型、细胞培养和临床试验中被探索,但这些又引起了更多的问题。本文就近年来PD病发病机制的研究进展做一综述。

Peyronie′s disease（PD） is a localized connective tissue disorder leading to the formation of fibrous plaques in tunica albuginea and erectile tissue. These plaques contain excessive amounts of collagen and fibroelastic proliferation that leads to different degrees of curvature and narrowing as well as penile pain and erectile dysfunction（ED）. The pathogenesis remains uncertain and there is still controversy about the best management. The pathogenesis of PD has been explored in animal models, cell cultures and clinical trials, but the results have led to further questions. This article reviews the research progress in the pathogenesis of PD in recent years.