ICU慢性阻塞性肺疾病急性加重期病原菌构成及耐药性

Composition and resistance of pathogenic bacteria in acute exacerbation of chronic obstructive pulmonary disease in ICU

目的分析ICU中慢性阻塞性肺疾病(COPD)急性加重期患者痰培养病原菌的构成及其耐药情况。方法以我院ICU收治的256例COPD急性加重期患者为研究对象,统计患者病原菌的构成及耐药菌的分布情况。结果阳性痰培养结果中,革兰阴性菌的构成比最高(84.21%)。药敏试验中革兰阳性菌对青霉素的耐药率最高,而对万古霉素、利奈唑胺及替加环素未见耐药;革兰阴性菌对不同抗生素的耐药性不同,其中对左氧氟沙星、哌拉西林及亚胺培南的的敏感性较高。结论在ICU中COPD急性加重期患者中,革兰阴性菌的感染比例高,且不同病原菌对不同抗生素的耐药性不同。

Objective To analyze the composition and drug resistance of sputum culture pathogen in patients with acuteexacerbation of chronic obstructive pulmonary disease （COPD） in ICU. Methods Two hundred and fifty-six patients withacute exacerbation of COPD in ICU of our hospital were selected as the research objects. The composition of pathogenicbacteria and the distribution of drug-resistant bacteria were analyzed. Results In the culture results of positive sputum, thecomposition ratio of Gram-negative bacteria was the highest （84.21%）. The resistance rate of Gram-positive bacteria topenicillin was the highest, but had no resistance to vancomycin, linazolamine and tegicycline. The Gram-negative bacteriahad different resistance to different antibiotics, with high sensitivity to levofloxacin, peracillin and imipenan. Conclusion InICU patients with acute exacerbation of COPD, the infection rate of Gram-negative bacteria is high. The resistance ofdifferent pathogens to different antibiotics is different.