腹腔镜逆行术对急性阑尾炎患者TNF-α、IL-6水平的影响和安全性

Effect and safety of laparoscopic retrograde surgery on TNF-α and IL-6 levels of patients with acute appendicitis

目的分析在临床中应用腹腔镜逆行术对急性阑尾炎患者TNF-α、IL-6水平的影响和安全性。方法选取在我院接受治疗的急性阑尾炎患者90例,随机将其分成对照组和研究组,各45例。对照组采用常规腹腔镜阑尾切除术进行治疗,研究组采用腹腔镜逆行术进行治疗。比较两组患者的手术时间、住院时间、TNF-α、IL-6水平变化以及并发症发生情况等。结果研究组患者的手术时间和住院时间显著短于对照组(P<0.05);术后48 h,两组患者的TNF-α与IL-6水平均升高,且对照组高于研究组(P<0.05);两组患者的并发症总发生率比较,差异无统计学的意义(P>0.05)。结论在临床中应用腹腔镜逆行术能有效地提高急性阑尾炎患者的康复速率,缓解机体的炎症反应,具有较高的安全性。

Objective To analyze the effect and safety of laparoscopic retrograde surgery on TNF-α and IL-6 levels ofpatients with acute appendicitis. Methods A total of 90 patients with acute appendicitis treated in our hospital wereselected and randomly divided into control group and study group, with 45 cases in each group. The control group wastreated with conventional laparoscopic appendectomy surgery, the study group was treated with laparoscopic retrogradesurgery. The surgery time, hospitalization time, TNF-α, IL-6 levels and complications of the two groups were compared.Results The surgery time and hospitalization time in the study group were significantly shorter than those in the controlgroup （P〈0.05）. At 48 h after surgery, the TNF-α, IL-6 levels increased in both groups, those in the control group werehigher than the study group（P〈0.05）. The total incidence of complications in the two groups was not statistically significant（P〉0.05）. Conclusion Application of laparoscopic retrograde surgery in clinical practice can effectively improve therecovery rate of patients with acute appendicitis, relieve the bodies＇ inflammatory response, which has a higher safety.