生血宁片治疗妊娠期缺铁性贫血疗效的Meta分析

Therapeutic Efficacy of Shengxuening Tablets in the Treatment of Iron-deficiency Anemia during Pregnancy:A Meta-analysis

目的:系统评价生血宁片治疗妊娠期缺铁性贫血的疗效,为临床提供循证参考。方法:计算机检索中国知网、万方、维普、PubMed等数据库中2008-2018年发表的关于生血宁片治疗妊娠期缺铁性贫血的临床随机对照试验(RCT),筛选文献、提取资料并采用改良后的Jadad评分量表评价纳入研究的质量,采用Stata 12.0软件进行Meta分析。结果:共纳入11项RCT,合计1 617例患者。生血宁片的总有效率均显著高于硫酸亚铁[OR=8.73,95%CI(2.96,25.69),P<0.05]、琥珀酸亚铁[OR=1.86,95%CI(1.04,3.33),P<0.05]和膳食调理[OR=3.43,95%CI(2.08,5.66),P<0.05],差异均有统计学意义。结论:生血宁片治疗妊娠期缺铁性贫血的疗效显著优于常规补铁剂。

OBJECTIVE：To evaluate therapeutic efficacy of Shengxuening tablets in the treatment of iron-deficiency anemia during pregnancy, so as to provide evidence for clinical decisions. METHODS： Retrieved from CNKI,Wanfang,VIP and PubMed,clinical randomized controlled trials（RCTs）about Shengxuening tablets in the treatment of iron-deficiency anemia during pregnancy were collected during 2008-2018. After screening literatures and extracted information, the literature quality was evaluated by using improved Jadad scale. Meta-analyses was performed by using Stata 12.0 software. RESULTS：A total of 11 RCTs were included,inulving 1 617 patients. Total response rate of Shengxuening tablets was significantly higher than those of ferrous sulfate [OR=8.73,95%CI（2.964,25.69）,P〈0.05],ferrous succinate [OR=1.86,95%CI（1.04,3.33）,P〈0.05] and dietory conditioning [OR=3.43,95% CI（2.08,5.66）,P〈0.05],with statistical significance. CONCLUSIONS：Therapeutic efficacy of Shengxuening tablets is significantly better than that of routine iron supplements in the treatment of iron-deficiency anemia during pregnancy.