胃癌内镜下活检组织中Vav1、CTSD表达量与临床生物学行为的相关性

The correlation of Vav1 and CTSD expression with the clinical biological behaviors in endoscopic biopsy gastric cancer tissue

目的:研究胃癌内镜下活检组织中Vav1、组织蛋白酶D(CTSD)表达量与临床生物学行为的相关性。方法:选择经胃镜下活检诊断为胃癌的患者,收集内镜下活检所得的胃癌组织及癌旁组织,测定Vav1、CTSD以及侵袭基因、增殖基因的表达量。结果:胃癌组织中Vav1、CTSD、HDAC5、Twist1、Ncadherin、MMP2、PTP1B、ATAD2、CyclinD1、PCNA的mRNA表达量显著高于癌旁组织,BTG3、WTX、FAF1、Fas、Mxi1的mRNA表达量显著低于癌旁组织;胃癌组织中Vav1、CTSD的mRNA表达量与HDAC5、Twist1、N-cadherin、MMP2、PTP1B、ATAD2、CyclinD1、PCNA的mRNA表达量呈正相关,与BTG3、WTX、FAF1、Fas、Mxi1的mRNA表达量呈负相关。结论:胃癌内镜下活检组织中Vav1、CTSD的高表达与肿瘤临床生物学行为相关的侵袭基因、增殖基因均具有相互作用的关系。

Objective：To study the correlation of Vav1 and cathepsin D（CTSD）expression with the clinical biological behaviors in endoscopic biopsy gastric cancer tissue.Methods：Patients who were diagnosed with gastric cancer by gastroscopic biopsy in The 252 Hospital of PLA between April 2015 and December 2017 were selected,and the gastric cancer tissues and adjacent tissues from endoscopic biopsy were collected to determine the expression of Vav1,CTSD,invasion genes and proliferation genes.Results：Vav1,CTSD,HDAC5,Twist1,N-cadherin,MMP2,PTP1 B,ATAD2,CyclinD1 and PCNA mRNA expression in gastric cancer tissues were significantly higher than those in adjacent tissues whereas BTG3,WTX,FAF1,Fas and Mxi1 mRNA expression were significantly lower than those in adjacent tissues;Vav1 and CTSD mRNA expression in gastric cancer tissues were positively correlated with HDAC5,Twist1,N-cadherin,MMP2,PTP1 B,ATAD2,CyclinD1 and PCNA mRNA expression,and negatively correlated with BTG3,WTX,FAF1,Fas and Mxi1 mRNA expression.Conclusion：The high expression of Vav1 and CTSD in the endoscopic biopsy gastric cancer tissues is correlated with the invasion genes and proliferation genes that are related to the clinical biological behaviors of the tumor.