曲唑酮治疗老年期痴呆并睡眠障碍的临床研究

Clinical Study of Trazodone in the Treatment of Senile Dementia Patients with Sleep Disorders

目的:分析老年期痴呆睡眠障碍患者采用曲唑酮实施药物治疗的临床效果。方法:选取2015年3月-2017年3月在我院接受药物治疗的老年期痴呆并睡眠障碍的患者80例,将其随机分为对照组和治疗组,每组40例。对照组采用阿米替林进行治疗;治疗组采用曲唑酮进行治疗,2组均连续用药1个月。比较2组患者药物治疗总有效率、药物原因导致的不良反应、用药前后匹兹堡睡眠质量指数量表评分改善幅度、治疗总时间。结果:治疗组患者药物治疗总有效率为92.5%,高于对照组的72.5%,组间差异有统计学意义(P<0.05);治疗组仅有1例(2.50%)药物原因导致的不良反应出现,少于对照组的6例(15.00%),组间差异有统计学意义(P<0.05);用药后2组匹兹堡睡眠质量指数量表评分均较用药前降低(P<0.05),且治疗组低于对照组(P<0.05)。对照组治疗周期为(26.37±3.54)d,治疗组治疗周期为(20.72±2.35)d,治疗组治疗周期较对照组明显缩短,组间差异有统计学意义(P<0.05)。结论:老年期痴呆睡眠障碍患者采用曲唑酮实施药物治疗可以减少药物不良反应,迅速控制症状并改善睡眠状态,缩短用药时间。

Objective： To investigate the clinical effect of Trazodone in the treatment of senile dementia patients with sleep disorders. Methods： A total of 80 cases of patients with senile dementia patients with sleep disorders were selected in our hospital in March 2015-2017 March,they were randomly divided into the control group and the treatment group,with an average of 40 cases in each group. The control group was treated with amitriptyline,and the treatment group was treated with trazodone,and the two groups were treated for one month. The total effective rate of drug treatment,adverse drug reactions caused by drugs,of pittsburgh sleep quality index score improvement before and after the administration and total time of treatment in the two groups was compared. Results： The total effective rate of drug treatment in the treatment group was 92. 5%,which was higher than that of the control group（ 72. 5%）,and the difference between the groups was significant（ P 〈 0. 05）. In the treatment group,only 1 cases（ 2. 50%） had adverse drug reactions,which were less than6 cases（ 15%） in the control group,the difference between the two groups was significant（ P 〈 0. 05）. After treatment,Pittsburgh sleep quality index score in the two groups decreased（ P 〈 0. 05）,and the treatment group was lower than the control group（ P 〈 0. 05）. The treatment period in the control group was（ 26. 37 ± 3. 54） d,and the treatment period in the treatment group was（ 20. 72 ± 2. 35） d. The treatment period in the treatment group was significantly shorter than that in the control group,and there was a significant difference between the two groups（ P 〈 0. 05）. Conclusion：The use of trazodone in the treatment of senile dementia patients with sleep disorders can reduce adverse drug reactions,control symptoms and improve sleep state,and shorten the time of medication.