2型糖尿病患者血清铁蛋白与周围血管病变的关系

Relationship of serum ferritin and peripheral vascular disease in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清铁蛋白(serum ferritin,SF)水平与周围血管病变的关系。方法依据颈动脉内膜中层厚度(carotid intima-media thickness,CIMT),将88例T2DM患者分为非颈动脉粥样硬化(non-carotid atherosclerosis,NCAS)组和颈动脉粥样硬化(carotid atherosclerosis,CAS)组。比较两组患者的一般情况、代谢参数以及SF水平。结果与NCAS组相比,CAS组患者年龄大,病程长,甘油三酯(TG)、收缩压、尿微量白蛋白、尿酸(UA)和SF水平均显著增高,Logistic回归分析显示TG、铁蛋白、病程以及年龄均为2型糖尿病伴有颈动脉粥样硬化的危险因素(P<0.05)。结论 2型糖尿病患者血清铁蛋白水平上升与周围血管病变之间关系密切。

Objective To diseuss the relationship between the serum ferritin （SF） level and peripheral vaseular disease in patients with type 2 diabetes mellitus （T2DM）. Methods 88 T2DM patients were divided into non-earotid atheroselerosis （NCAS） group and earotid atheroselerosis （CAS） group based on the earotid intima-media thiekness （CIMT）. The general eonditions, metabolie parameters and $F in two groups were eompared. Results Compared with NCAS group, the patients in CAS group were older and had a longer eourse of disease. Triglyeeride （TG）, systolie pressure, mieroalbuminuria, urie acid （IDA） and $F levels were remarkably higher in CAS group than those in NCAS group. Logistie regression analysis indieated that TG, ferritin, eourse of disease and age were the risk faetors of T2DM eompared with CAS （P〈0.05）. Conclusion The elevated SF level is elosely assoeiated with peripheral vaseular disease in T2DM patients.