尼卡地平治疗急性脑出血69例疗效与安全性评价

Effect and Safety of Nicardipine in the Treatment of 69 Patients with Acute Cerebral Hemorrhage

目的探讨尼卡地平治疗急性脑出血患者的疗效与安全性。方法选取医院2015年6月至2017年6月急性脑出血患者138例,均分为对照组和观察组,各69例。对照组患者给予乌拉地尔降压,观察组患者给予尼卡地平降压。结果用药前,两组患者的舒张压、收缩压、心率比较,差异无统计学意义(P>0.05);用药后,两组患者舒张压、收缩压均降低,心率升高,且观察组患者变化幅度高于对照组(P<0.05);观察组患者的目标血压到达时间低于对照组患者(P<0.05),24 h内血压达标率高于对照组患者(P<0.05)。观察组临床总有效率为92.75%,高于对照组的79.71%(P<0.05);观察组患者不良反应总发生率为17.39%,低于对照组的39.13%(P<0.05)。结论急性脑出血患者初期给予尼卡地平可有效降低血压,改善心率和临床疗效,降低不良反应发生率。

Objective To investigate the effect and safety of nicardipine in the treatment of patients with acute cerebral hemorrhage.Methods Totally 138 patients with acute cerebral hemorrhage admitted to our hospital from June 2015 to June 2017 were selected and equally divided into the control group and the observation group,69 cases in each group. The control group was given urapidil to reduce blood pressure,while the observation group was given nicardipine to reduce blood pressure. Results Before treatment,the diastolic blood pressure（ DBP）,systolic blood pressure（ SBP） and heart rate（ HR） in the two groups had no significant difference（ P 0. 05）, after treatment, the DBP and SBP in the two groups were decreased, while the HR was increased, and the improvement of the observation group was more significant（ P 0. 05） The time of reaching target blood pressure in the observation group was shorter than that in the control group,and the compliance rate of blood pressure within 24 h in the observation group was higher than that in the control group（ P 0. 05）. The total effective rate of the observation group was 92. 75 %, which was higher than 79. 71 % of the control group（ P 0. 05）, and the total incidence rate of adverse reactions in the observation group was 17. 39%, which was lower than 39. 13%in the control group（ P 0. 05）. Conclusion Nicardipine in the treatment of patients with acute cerebral hemorrhage in the early stage can effectively decrease blood pressure,improve HR and clinical effect,reduce the incidence rate of adverse reactions.