中性粒细胞/淋巴细胞比值与冠心病及Gensini评分的相关性研究

Study on the Relationship Among Neutrophil Lymphocyte Ratio,Coronary Artery Disease and Gensini Score

目的:探讨中性粒细胞/淋巴细胞比值(neutrophil lymphocyte ratio,NLR)与冠心病(coronary artery disease,CAD)及Gensini评分的关系。方法:选取行冠状动脉造影的患者183例,根据造影结果将入选者分为CAD组(123例)和非CAD组(60例)。收集入选者的一般特征资料及血生化检验结果资料,计算中性粒细胞/淋巴细胞比值(NLR)及入选者的Gensini评分,分析NLR与冠心病及Gensini评分之间的关系。结果:NLR在CAD组(3.55±1.56)值显著高于非CAD组(2.41±0.90),差异有统计学意义(P<0.001)。多因素Logistic回归分析显示NLR(OR=2.752,95%CI:1.729~4.38)为CAD的独立危险因素。将Gensini评分及NLR进行Pearson相关分析显示,Gensini评分与NLR水平呈正相关(r=0.426,P<0.001)。结论:NLR水平与CAD密切相关,且与代表冠脉狭窄程度的Gensini评分相关。

Objective： To investigate the relationship between neutrophil lymphocyte ratio,coronary artery disease and Gensini score. Methods： Patients were divided into coronary artery disease（ CAD） group（ 123 cases） and Non-CAD group（ 60 cases） according to coronary angiography（ CAG） results.The baseline data and blood biochemical data of all patients were collected.NLR and Gensini score were calculated and the relationship of them were analyzed. Results： The NLR were higher in CAD group（ 3.55±1.56） compared with Non-CAD group（ 2.41±0.90）（ P〈0.001）.Multivariate Logistic regression analysis showed that NLR（ OR =2.752,95% CI： 1.729-4.38） was an independent risk factors of CAD.The Pearson regression analysis showed that it was a positive correlation between Gensini score and NLR（ r = 0. 426,P〈0. 001）. Conclusion： The level of NLR was closely related to CAD and correlated with the Gensini score representing the degree of coronary stenosis.