派丽奥软膏联合替硝唑治疗慢性牙周炎的疗效及对血清与龈沟液IL-17 IL-35表达的影响

Effect of the Treatment of Chronic Periodontitis and Expressionl of IL-17 and IL-35 in Serum and Gingival Crevicular Fluid

目的:探讨派丽奥软膏联合替硝唑治疗慢性牙周炎的疗效及对血清与龈沟液IL-17、IL-35表达的影响。方法:选择2014年1月至2016年12月慢性牙周炎患者130例,随机分为观察组和对照组,各65例。对照组给予替硝唑进行治疗,观察组在此基础上加以派丽奥软膏进行治疗。治疗4周后,比较两组患者临床疗效、牙龈指数(GI)、牙菌斑指数(PLI)、牙周附着水平(PAL)、牙周袋深度(PPD)、牙齿松动度(MD)、白细胞介素-17(IL-17)、白细胞介素-35(IL-35)及不良反应。结果:经治疗,观察组总有效率高于对照组(92.31%vs 73.85%,P<0.05);观察组患者GI、PLI、PAL、PPD及MD均明显低于对照组(P<0.05);观察组龈沟液IL-17、IL-35水平均低于对照组(351.64±41.73vs394.35±46.17 100.44±7.19)vs143.25±9.64 P<0.05);观察组血清IL-17、IL-35水平均低于对照组[(16.05±1.07)vs(20.64±1.83)ng/L,(100.44±7.19)vs(258.17±16.94)ng/m L](P<0.05);观察组不良反应总发生率低于对照组(6.15%vs18.46%,P<0.05)。结论:派丽奥软膏联合替硝唑治疗慢性牙周炎疗效确切,可有效缓解临床症状,同时改善龈沟液IL-17、IL-35表达,提高机体免疫功能,且不良反应少,值得推广应用。

Objective： To investigate the effect of the combination of IL-17 and IL-35 in the treatment of chronic periodontitis and the expression of serum and gingival crevicular fluid. Methods： 130 patients of chronic periodontitis received therapy from Jan 2014 to Dec 2016 in our hospital were selected as the research object. All the patients were randomly divided into observation group and control group,each group of 65 cases. The control group was given tinidazole treatment,the observation group was treated with periocline ointment on this basis. After 4 weeks of treatment,the clinical efficacy,gingival index（ GI）,plaque index（ PLI）,periodontal attachment（ PAL）,periodontal pocket depth（ PPD）,tooth mobility（ MD）,Interleukin-17（ IL-17）,interleukin-35（ IL-35） and adverse reactions were compared. Results After treatment,the observation group,the total effective rate was higher than the control group（ 92.31% vs 73.85%,P〈0.05）;The GI,PLI,PAL,PPD and MD in the observation group were significantly lower than those in the control group（ P〈0.05）; The levels of IL-17 and IL-35 in gingival crevicular fluid in observation group were lower than those in control group（ 351.64±41.73 vs 394.35±46.17,100.44±7.19 vs 143.25±9.64,P〈0.05）; The levels of IL-17 and IL-35 in the observation group were lower than those in the control groupf[（ 16.05±1.07）vs（ 20.64±1.83） ng/L,（ 100.44±7.19） vs（ 258.17±16.94） ng/ml]（ P〈0.05）; The total incidence of adverse reactions in the observation group was lower than that in the control group（ 6. 15% vs 18. 46%,P〈0. 05）.Conclusion： It can effectively relieve the clinical symptoms,improve the expression of IL-17 and IL-35 in gingival crevicular fluid,improve the immune function of the body,and have less adverse reactions. It is worth popularizing.