静电纺丝素纳米纤维在生物医学组织工程领域的研究进展

Research progress of electrospinning nanofibers used in biomedical tissue engineering

利用静电纺丝技术以丝素蛋白为主要原料制备直径与天然细胞外基质(ECMs)结构相近的纳米纤维,使丝素蛋白支架能够较好地仿生人体内ECMs结构,让种子细胞可在支架多孔三维网络状结构上很好地黏附、增殖,并提供细胞基质、维持细胞生长并保持分化功能,满足组织修复和重建的要求,是目前生物技术应用医学领域的研究热点。本文主要综述了近年来国内外静电纺丝制备丝素蛋白纳米纤维材料在组织工程领域应用的研究现状,并对静电纺SF纳米纤维未来应用的发展作了展望。

By using electrostatic spinning technology,the preparation of nanofibers with silk fibroin as the main raw material can be similar to and the diameter of the natural extracellular matrix（ECMs）structure,the silk fibroin nanofibers scaffolds can simulate the ECMs structure in the human body,and can let the seed cells better to adhere,proliferate and matrix in the porous three-dimensional reticular structure,and provide cell matrix,maintain cell growth and differentiation function,meeting the requirements of tissue repair and reconstruction,which is a hot spot in the biological technology application in the field of medicine.In this paper,the research status of the application of electrospinning silk fibroin nanofibers in the field of tissue engineering in recent years is reviewed,and the future development of electrospinning SF nanofibers is prospected.