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Ⅳ期肺癌合并肺血栓栓塞的危险因素分析 被引量:1

Analysis for risk factors of pulmonary thromboembolism in the stage Ⅳ of lung cancer
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摘要 目的分析Ⅳ期肺癌合并肺血栓栓塞患者的临床特征及实验室检验结果,寻找其发生肺血栓栓塞的危险因素。方法选取2011年1月—2017年10月南昌大学第一附属医院就诊的70例Ⅳ期肺癌患者。收集血常规、血生化、凝血功能、肿瘤标志物(CEA,CA199,CA125,NSE,Cyfra21-1)及多层螺旋CT肺动脉成像CTPA检查,单因素分析影响Ⅳ期肺癌合并肺血栓栓塞的可疑危险因素,对单因素分析有意义的因素进行多因素Logistic回归分析。结果单因素分析显示,血白蛋白降低,血白细胞、中性粒细胞百分比和Cyfra21-1增高及异常肿瘤标志物的数量增多是Ⅳ期肺癌患者发生肺血栓栓塞的危险因素。多因素Logistic回归分析显示,异常肿瘤标志物的数量≥4(OR=7.016,95%CI:1.916~25.686)是Ⅳ期肺癌发生肺血栓栓塞的独立危险因素。结论异常肿瘤标志物的数量是Ⅳ期肺癌发生肺血栓栓塞的独立危险因素,当异常肿瘤标志物的数量≥4个时需高度警惕Ⅳ期肺癌合并肺血栓栓塞的可能。 Objective The aims of this study were to analyze the clinical characteristics and laboratory test results of stageⅣ lung cancer patients with Pulmonary thromboembolism( PTE),and to find out the risk factors for pulmonary thromboembolism.Methods A total of 70 patients with stage IV lung cancer were selected from the First Affiliated Hospital of Nan Chang University from January 2011 to October 2017. Blood routine,blood biochemistry,coagulation function,tumor markers( CEA,CA199,CA125,NSE,Cyfra211) and multi-slice spiral CT pulmonary angiography( CTPA) were collected in these patients. Univariate analysis was applied to compare the clinical features and laboratory tests between PTE and non-PTE groups. Multivariate logistic regression analysis was applied to explore significant risk factors of PTE. Results Univariate analysis showed that serum albumin,blood leukocyte,neutrophil percentage,increased Cyfra211 and abnormal tumor markers were risk factors for PTE in patients with stage IV lung cancer. Multivariate logistic regression analysis showed that the number of abnormal tumor markers ≥ 4( OR = 7. 016,95% CI: 1. 916 ~25. 686) was an independent risk factor for PTE in stage IV lung cancer. Conclusion The number of abnormal tumor markers is an independent risk factor for pulmonary thromboembolism in stage Ⅳ lung cancer. When the number of abnormal tumor markers is ≥4,it is necessary to highly alert the possibility of stage IV lung cancer with pulmonary thromboembolism.
作者 万静萱 李红红 周湘乡 马琳 WAN Jingxuan;LI Honghong;ZHOU Xiangxiang;Ma Lin(Department of Respiration,The First Affiliated Hospital of Nan Chang University,Nanchang 330006,China)
出处 《实用肿瘤学杂志》 CAS 2018年第3期241-244,共4页 Practical Oncology Journal
关键词 肺血栓栓塞 Ⅳ期肺癌 肿瘤标志物 危险因素 Pulmonary thromboembolism Stage Ⅳ of lung cancer Tumor markers Risk factors
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