月经失调女性抗缪勒氏管激素与卵泡刺激素关系的研究

Study on Relationship of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Women with Menstrual Disorders

目的:探讨月经失调女性抗缪勒氏管激素(anti-Mullerian hormone,AMH)与卵泡刺激素(follicle-stimulating hormone,FSH)变化趋势及两者之间的相关性。方法:选取2017年1-9月本院就诊的106例月经失调育龄期女性为研究对象,按年龄段分为5组:A组(21~25岁,17例)、B组(26~30岁,23例)、C组(31~35岁,27例)、D组(36~40岁,21例)、E组(>41岁,18例)。检测并观察五组血清AMH、FSH水平及其两者相互间的关系。结果:血清AMH水平随年龄的增加而降低,与年龄呈负相关(r=-0.560,P<0.000 1)。五组血清AMH水平比较,差异均有统计学意义(P<0.05)。血清FSH水平则随年龄增长而缓慢上升(r=0.086,P=0.391)。A组血清FSH水平低于B组,差异有统计学意义(P<0.05);其余各组血清FSH水平比较,差异均无统计学意义(P>0.05)。血清AMH与FSH呈负相关,差异无统计学意义(r=-0.126,P=0.256)。结论:年龄是影响月经失调女性AMH水平重要因素,其与年龄相关性优于FSH,而AMH与FSH相关性不强,在月经失调患者中用AMH水平预测FSH不可取。

Objective：To investigate the relationship and the alteration tendency of anti-Mullerian hormone（AMH） and follicle-stimulating（FSH） in women with menstrual disorders.Method：A total of 106 cases with menstrual disorders in our hospital from January to September 2017 were divided into group A（21-25 years old,17 cases）,group B（26-30 years old,23 cases）,group C（31-35 years old,27 cases）,group D（36-40 years old,21 cases）,group E（41 years old,18 cases）according to the different age bracket.The levels of AMH and FSH in serum were detected and observed among the five groups.Result：There was a negative correlation with age and the levels of AMH（r=-0.560,P0.000 1）.There were statistically significant in the levels of AMH among the five groups（P〈0.05）.With the growth of age,the levels of FSH was slowly increasing（r=0.086,P=0.391）.The level of FSH in group A was lower than that in the group B,the difference was statistically significant（P〈0.05）;there were no statistically significan in the levels of FSH in the others groups（P〈0.05）.Conclusion：Age is an important factor affecting the levels of AMH in women with menstrual disorders.There is no strong correlation between AMH and FSH,with a better correlation with age in the levels of AMH.So it is not advisable to predict FSH with AMH levels in women with menstrual disorders.