MRI对宫颈癌子宫动脉化疗栓塞治疗疗效的评价

Evaluation of Magnetic Resonance Imaging for the Treatment Effect of Uterine Artery Chemoembolization in Cervical Cancer

目的探讨MRI对子宫动脉化疗栓塞治疗宫颈癌疗效的评价价值。方法回顾性分析经病理证实的44例宫颈癌患者的临床、MRI资料,所有患者均行子宫动脉化疗栓塞术治疗且术前、术后均行MR检查,评估治疗前后MRI影像变化。结果术前MRI诊断宫颈癌病灶最大径平均值为(4.7±1.4)cm,术后病灶最大径平均值为(2.9±1.5)cm,治疗前后病灶最大径差异有统计学意义,P<0.05;对比治疗前后宫颈癌病灶的ADC值,治疗前平均值为(0.904±0.2230)×10-3mm^2/s,治疗后平均值为(1.041±0.231)×10-3mm^2/s,二者差异有统计学意义,P<0.05;鳞癌治疗有效率86.1%,高于其他病理类型总有效率50.0%,P<0.05;对比鳞状细胞癌治疗前后ADC值变化,治疗前后两者差异有统计学意义,P<0.05;对比其他病理类型宫颈癌治疗前后变化,二者差异无统计学意义,P>0.05。结论 MRI有助于早期评价子宫动脉化疗栓塞治疗的疗效;且鳞状细胞癌对该治疗方案的反应优于其他病理类型宫颈癌。

Objective To analyze the value of magnetic resonance imaging in assessing the effect of uterine artery chemoembolization of cervical cancer. Methods The retrospective analysis was performed in the clinical, MRI and pathological information of 44 cervical cancer patients. All the patients accepted the Uterine artery chemoembolization and the MRI examination was performed before and after the treatment. The variation of MRI images was evaluated before and after the treatment. Results The MRI diagnosis before the operation shows the average value of the maximum diameter of the focus was（4.7±1.4） cm, after the operation the average value of the maximum diameter of the focus was（2.9±1.5） cm. The change had the statistical significance, P0.05, to compared the ADC value of the cervical cancer lesions before and after the treatment, the average value before the treatment was（0.904±0.2230）×10-3 mm^2/s, the average value after the treatment was（1.041±0.231）×10-3 mm^2/s and the difference between them had the statistics significance, P0.05, patients with squamous cell carcinoma showed a better response rather than patients with other pathological types（86.1% vs. 50.0%）, P0.05. To compared the variation of ADC value of squamous-cell carcinoma before and after the treatment, the difference between them had the statistics significance, P0.05; to compared the variation of other pathological types of cervical cancer before and after the treatment, the change has no statistics significance, P0.05. Conclusion MRI may be useful for early evaluation the treatment effect of Uterine artery chemoembolization in cervical cancer and the response of this treatment plan of the squamous cell cancer was better than that of the cervical cancer of other pathological types.