MRI结合肿瘤标志物在诊断前列腺癌中的应用

Application of MRI Combined with Tumor Markers in the Diagnosis of Prostatic Cancer

目的探究核磁共振成像(MRI)结合肿瘤标志物在前列腺癌(PCa)诊断中的临床应用效果。方法回顾性分析86例前列腺疾病患者临床资料,根据组织学穿刺活检结果良恶性分为PCa组(n=35)与良性前列腺增生(BPH)组(n=51)。所有患者均接受MRI与血清前列腺特异抗原(PSA)检测,比较两组患者PSA相关指标水平异同,并分析单纯检测PSA、MRI及二者联合检查诊断准确性差异。结果两组患者PSA相关指标水平均存在明显差异(P均<0.05)。MRI联合PSA检测对PCa的诊断符合率为93.02%(80/86),明显高于两种单纯检测方法(P均<0.05)。结论 MRI结合肿瘤标志物诊断PCa准确性较高,有良好的临床应用前景。

Objective To explore the clinical application of magnetic resonance imaging（MRI） combined with tumor markers in the diagnosis of prostatic cancer（PCa）. Methods The clinical data of 86 patients with prostatic cancer were analyzed retrospectively. According to the results of histological biopsy and benign and malignant condition, the patients were divided into PCa group（n=35） and benign prostatic hyperplasia（BPH） group（n=51）. All patients were detected by MRI and serum prostate specific antigen（PSA）, and the levels of PSA related indicators were compared between the two groups, and differences in diagnostic accuracy of simple PSA, or MRI detection and the two combination were analyzed. Results There were significant differences in the levels of PSA related indicators between the two groups（all P〈0.05）. The diagnostic coincidence rate of MRI combined with PSA was 93.02%（80/86） in the detection of PCa, which was significantly higher than that of the two simple detection methods（all P〈0.05）. Conclusion MRI combined with tumor markers has high accuracy in the diagnosis of PCa, and it has a good prospect in clinical application.